Cytomegalovirus Infection in Solid Organ and Hematopoietic Cell Transplantation: State of the Evidence.

The Journal of Infectious Diseases
Ghady HaidarNina Singh

Abstract

This review focuses on recent advances in the field of cytomegalovirus (CMV). The 2 main strategies for CMV prevention are prophylaxis and preemptive therapy. Prophylaxis effectively prevents CMV infection after solid organ transplantation (SOT) but is associated with high rates of neutropenia and delayed-onset postprophylaxis disease. In contrast, preemptive therapy has the advantage of leading to lower rates of CMV disease and robust humoral and T-cell responses. It is widely used in hematopoietic cell transplant recipients but is infrequently utilized after SOT due to logistical considerations, though these may be overcome by novel methods to monitor CMV viremia using self-testing platforms. We review recent developments in CMV immune monitoring, vaccination, and monoclonal antibodies, all of which have the potential to become part of integrated strategies that rely on viral load monitoring and immune responses. We discuss novel therapeutic options for drug-resistant or refractory CMV infection, including maribavir, letermovir, and adoptive T-cell transfer. We also explore the role of donor factors in transmitting CMV after SOT. Finally, we propose a framework with which to approach CMV prevention in the foreseeable future.

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Citations

Jul 17, 2020·Frontiers in Cellular and Infection Microbiology·Charlotte J HouldcroftMark R Wills
Nov 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hannah N Imlay, Daniel R Kaul
Feb 18, 2021·JAMA Dermatology·Nelson UgwuCaroline A Nelson
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May 11, 2021·Frontiers in Immunology·Estéfani García-RíosPilar Pérez-Romero
Jul 4, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Andrew H KarabaRobin K Avery
Sep 28, 2021·Frontiers in Immunology·Katrin LazarKilian Wistuba-Hamprecht
Oct 30, 2021·Clinical Pharmacology in Drug Development·Dirk KropeitHelga Rübsamen-Schaeff

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