Cytomegalovirus infection in symptomatic periapical pathosis

International Endodontic Journal
J SlotsM Sabeti

Abstract

To compare the presence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) infections in samples from 25 symptomatic and 19 asymptomatic periapical lesions. Periapical samples were collected by sterile curettes in conjunction with apicectomy. cDNA-based HCMV and EBV identification was performed on total mRNAs extracted from peripapical tissues, using primers for genes transcribed during the productive phase of the herpesvirus infection. Statistical analysis was performed using chi-squared test. HCMV was detected in 100% of the symptomatic and in 37% of the asymptomatic study lesions. EBV was identified only in HCMV-infected periapical lesions. The difference in occurrence of HCMV and EBV between symptomatic and asymptomatic periapical lesions was statistically significant (P < 0.0001). The noteworthy finding of this study was the ubiquitous occurrence of HCMV active infection in symptomatic periapical pathosis. EBV may contribute to periapical pathogenesis in a subset of symptomatic lesions. HCMV and EBV infections may cause periapical pathosis by inducing cytokine and chemokine release from inflammatory or connective tissue cells, or by impairing local host defences resulting in heightened virulence of resident bacte...Continue Reading

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Nov 30, 2007·Clinical Oral Investigations·C J Saboia-DantasM J S Pereira
Jun 1, 2013·Medicina oral, patología oral y cirugía bucal·Selcuk-M OzbekMuhammed-Selim Yavuz
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Dec 3, 2021·Reviews in Medical Virology·Pari ThakkarAfsar R Naqvi

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