Cytomegalovirus infection of the cervix: morphological observations in five cases of a possibly under-recognised condition

Journal of Clinical Pathology
C E McGalieW G McCluggage

Abstract

Histologically diagnosed cytomegalovirus (CMV) infection of the cervix is rare and the associated morphological features are not well described. This study describes histopathological findings in five biopsies from four patients with CMV cervicitis. CMV inclusions were identified in five cervical biopsies from four patients in a single institution over eight months. The clinical notes were reviewed, the morphological features documented, and immunohistochemical staining for CMV performed. CMV immunohistochemical staining was also performed on 30 consecutive cervical biopsies in which inclusions were not seen histologically. None of the patients was immunocompromised but one was postnatal. Numbers of CMV inclusions ranged from occasional to abundant and they were located mainly in endocervical glandular epithelial cells but also in endothelial and mesenchymal cells. Inclusions were not seen in squamous cells. Inclusions were eosinophilic and were intracytoplasmic rather than intranuclear. They were positive immunohistochemically for CMV. Associated morphological features included fibrin thrombi within small blood vessels (three cases), dense active inflammatory infiltrates (five cases), lymphoid follicles (two cases), vacuolatio...Continue Reading

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Citations

Mar 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeanne M Marrazzo, David H Martin
Nov 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer SlykerVincent Emery
Mar 17, 2007·Pathology·W Glenn McCluggage
Jun 16, 2009·Diagnostic Cytopathology·Fadi BrimoManon Auger
Aug 19, 2007·Diagnostic Cytopathology·Girish VenkataramanChristine N Booth
Oct 25, 2011·Diagnostic Cytopathology·Qiuying ShiRobert J Cabay
Jun 15, 2013·Journal of Medical Virology·Joana Marinho-DiasHugo Sousa
Jun 21, 2005·Infectious Disease Clinics of North America·Jeanne M Marrazzo
Jan 15, 2008·Current Opinion in Infectious Diseases·M Josephine Lusk, Pam Konecny

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