Cytomegalovirus is not associated with progression and metastasis of colorectal cancer

Cancer Letters
Thomas KnöselIver Petersen

Abstract

Recently, it was hypothesized that human cytomegalovirus (HCMV) might be associated with colorectal cancer progression. However, the role of HCMV infection in colorectal cancer remains controversial. We aimed to assess whether nucleic acids and/or gene products of HCMV could be detected in primary and metastatic colorectal carcinomas. Fresh-frozen biopsy specimens from 77 primary and metastatic colorectal carcinomas of randomly selected patients were analyzed by PCR and immunohistochemistry. We investigated 57 primary tumors and 20 metastases, comprising 13 tumor pairs from the same patient. In PCR, four primary tumors showed a positive CMV result whereas all investigated metastases were negative including three paired samples from positive primaries. In immunohistochemistry, no specific staining could be determined in all neoplastic epithelial cells. In summary, we think that there is no association between CMV infection and tumor progression or metastasis formation of colorectal cancer.

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Citations

Oct 28, 2010·The Journal of Clinical Investigation·Gerold BongersSergio A Lira
Apr 18, 2009·Infectious Agents and Cancer·Cecilia BenderUmberto Bertazzoni
Apr 6, 2013·Infectious Agents and Cancer·Dolores Utrera-BarillasMartha-Eugenia Ruiz-Tachiquin
Nov 12, 2010·The Lancet Oncology·Danielle CollinsDesmond C Winter
Feb 3, 2009·Pathology, Research and Practice·Thomas KnöselIver Petersen
Jan 27, 2009·International Journal of Cancer. Journal International Du Cancer·Valentina MilitelloLuisa Barzon
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M ParkJ-H Kang
May 24, 2006·Scandinavian Journal of Gastroenterology·Tetsu KojimaHirokazu Nagawa
Sep 27, 2019·Nature Reviews. Gastroenterology & Hepatology·Sunny H Wong, Jun Yu
Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Farzaneh Tafvizi, Zahra Tahmasebi Fard
Nov 5, 2020·International Journal of Molecular Sciences·Martin MarônekCarmine Stolfi

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