Cytomegalovirus pneumonia in AIDS patients: value of cytomegalovirus culture from BAL fluid and correlation with lung disease

Chest
C Uberti-FoppaA Lazzarin

Abstract

To verify the value of cytomegalovirus (CMV) cultures of BAL fluid vs postmortem lung histopathology in detecting CMV pneumonia, and to correlate the BAL viral dose with the number of CMV inclusion bodies (CMV-IB) in the lung tissue of AIDS patients. Retrospective analysis of 434 BALs and 40 autopsies involving 307 AIDS patients; clinical follow-up lasted 10 months. The 40 patients who died within 20 days of undergoing BAL were divided on the basis of histopathologic findings into subjects with and without CMV-IB in the lung tissue. The relationship between the BAL viral dose and CMV lung infection was evaluated by counting the early antigen (CMV-EA) positive cells/200 microL of BAL and the number of CMV-IB/mm2 of lung tissue. The predictive value of BAL virus isolation for the diagnosis of CMV pneumonia was 61% for positive and 100% for negative results. The patients with the largest number of CMV-IB had CMV-EA counts from 2 to 840; in those with a moderate and small number, the CMV-EA counts were, respectively, from 11 to 700 and 2 to 300. Among the patients surviving up to 10 months after the BAL index sample, the frequency of recurrent extrapulmonary CMV abnormalities was 27% in those with positive and 7% in those with nega...Continue Reading

References

Aug 1, 1988·Diagnostic Microbiology and Infectious Disease·A EriceH H Balfour
May 1, 1987·The Journal of Infectious Diseases·J E ThorpeJ L Staneck
May 1, 1997·American Journal of Respiratory and Critical Care Medicine·M MannF P Ognibene

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Citations

Jul 24, 2002·Archives of Pharmacal Research·Rafik SamuelByungse Suh
Apr 29, 2006·Current Infectious Disease Reports·Erik Langhoff, Robert E Siegel
Nov 28, 2001·Cytopathology : Official Journal of the British Society for Clinical Cytology·G Kocjan, R Miller
Dec 15, 2010·The Pediatric Infectious Disease Journal·Marco ZampoliHeather J Zar
Jun 20, 2008·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Sandro Cinti
Dec 12, 2001·American Journal of Respiratory and Critical Care Medicine·J M BeckH H Peavy
Mar 23, 2011·Arhiv za higijenu rada i toksikologiju·Kornelija MišeJoško Miše
Oct 3, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Kuan-Yeh LeeShan-Chwen Chang
Feb 13, 2008·Clinics in Chest Medicine·Loren KetaiEdith M Marom
Dec 19, 2006·Seminars in Roentgenology·Galit AviramPhillip M Boiselle
Jun 25, 2010·Pediatric Pulmonology·P GoussardJ T Janson
May 25, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Antonio CascioWalter Fries
Jun 4, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Nei-Yuan HsiaoDiana Hardie
Sep 15, 2010·Journal of Intensive Care Medicine·Karen Joan VigilRoy F Chemaly
Nov 18, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E F de MaarW J van Son

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