Cytomegalovirus prevalence and transmission after islet allograft transplant in patients with type 1 diabetes mellitus

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Muhammad M HafizR Alejandro

Abstract

Cytomegalovirus (CMV) serological status of transplant donors and recipients has important implications on antiviral prophylaxis, morbidity/mortality, donor selection and hospital stay. We evaluated CMV prevalence in our islet transplant candidates (ITC) in comparison with organ donors. We correlated the CMV serological status of our ITC with serology for Epstein-Barr virus and Parvovirus B19, auto-antibodies, patient's age, age at DM onset, duration of DM, gender, race, ABO group, HLA haplotype and C-peptide levels. Cytomegalovirus transmission after islet transplant using the Edmonton regimen was also evaluated. Cytomegalovirus seropositivity varied according to patient group, age, gender and race. Type 1 DM patients had reduced odds of CMV seropositivity when compared with organ donors. In all groups studied, older patients, females, and non-Caucasians were more likely to be CMV seropositive. In addition, no CMV reactivation, infection or disease was observed among our transplanted patients using this steroid-free regimen even after donor/recipient CMV mismatch.

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Citations

Jul 22, 2005·Current Diabetes Reports·Betul HatipogluJosé Oberholzer
Oct 27, 2007·Expert Opinion on Biological Therapy·Simona MarzoratiCamillo Ricordi
Jun 21, 2007·Transplantation Proceedings·N YakubovichD M Thompson
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Tatiana FroudRodolfo Alejandro
Apr 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P CureR Alejandro
Oct 16, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Davide MineoCamillo Ricordi
Jun 13, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·N BergerH Bonatti
Sep 13, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B L Gala-LopezA M J Shapiro
Dec 24, 2010·Cell Transplantation·M J SmeltP de Vos
Apr 18, 2007·Cell Transplantation·Gaston M PonteRodolfo Alejandro
Dec 9, 2017·Xenotransplantation·Claire CrossanLinda Scobie
Nov 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Supha K ArthursRaymund R Razonable
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brent H KoehnChristian P Larsen

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