PMID: 11926748Apr 3, 2002Paper

Cytomegalovirus prophylaxis with ganciclovir and cytomegalovirus immune globulin in liver and intestinal transplantation

Transplant Infectious Disease : an Official Journal of the Transplantation Society
A G Tzakis

Abstract

Liver and intestinal transplant recipients at the University of Miami receive an intensive regimen of cytomegalovirus (CMV) prophylactic therapy consisting of a combination of CMV immune globulin intravenous (CMV-IGIV, CytoGam) and ganciclovir. The 5-year experience with this regimen in liver transplant patients showed effective CMV prophylaxis in this patient population. The importance of an effective prophylactic strategy was underscored by higher observed rates of chronic rejection and post-transplant lymphoproliferative disorder (PTLD) in CMV-infected patients. The use of CMV-positive donors for intestinal transplants did not increase the incidence of CMV disease. Intestinal transplant recipients had improved survival rates, reflecting an aggressive policy of monitoring, immunosuppression, and CytoGam plus ganciclovir prophylaxis.

References

Sep 1, 1995·Annals of Surgery·S TodoT E Starzl
Nov 24, 1999·The American Journal of Gastroenterology·Y NivA G Tzakis

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Citations

Sep 16, 2003·Transplantation·Thomas M FishbeinNeal S LeLeiko
Jun 6, 2012·Transplantation Proceedings·V MüllerV S Schellerer
Nov 8, 2014·British Journal of Haematology·Augusto LauroAntonio D Pinna
Jul 15, 2004·International Immunopharmacology·Matthias BudtHartmut Hengel
Nov 16, 2004·Anesthesiology Clinics of North America·Bob H SaggiRonald W Busuttil
Jan 9, 2004·Pediatric Clinics of North America·Naveen K MittalJohn F Thompson
May 8, 2004·Reviews in Clinical and Experimental Hematology·Richard F Ambinder
Jun 12, 2018·Clinical Transplantation·Laura J WozniakDouglas G Farmer
Aug 8, 2008·Current Opinion in Organ Transplantation·Gabriel Gondolesi, Martin Fauda
Jul 13, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Daniel SeehoferPeter Neuhaus
Jan 24, 2015·Current Gastroenterology Reports·Chandrashekhar A KubalA Joseph Tector

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