Cytomegalovirus-related congenital nephrotic syndrome with diffuse mesangial sclerosis

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Nesrin BesbasAysin Bakkaloglu

Abstract

This case report describes congenital nephrotic syndrome in a 2-month-old girl associated with cytomegalovirus infection. Histological examination on renal biopsy showed diffuse mesangial sclerosis and cytomegalic inclusion bodies in the tubular cells and in some glomeruli. Cytomegalovirus (CMV) polymerase chain reaction (PCR) titer in serum was high. Remission of pulmonary and renal symptoms was achieved with ganciclovir in 3 weeks. No recurrence of proteinuria was observed during the follow-up period of 14 months. These finding suggested a causal relationship between congenital nephrotic syndrome and cytomegalovirus infection.

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Citations

Jul 17, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Asha MoudgilNaynesh Kamani
Oct 31, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hannu Jalanko
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Mar 11, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Scott E Wenderfer
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Dec 18, 2020·Frontiers in Pediatrics·Anju JacobMartin Bitzan
Jul 3, 2021·Microorganisms·María Ríos-BarnésAntoni Noguera-Julian

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