Cytomegalovirus Retinitis in a Human Immunodeficiency Virus-negative Cohort: Long-term Management and Complications

Ocular Immunology and Inflammation
Sohee Jeon, Won Ki Lee

Abstract

To examine the clinical outcomes achieved by using intravitreal ganciclovir injections combined with systemic anti-viral therapy in treating cytomegalovirus (CMV) retinitis in patients without human immunodeficiency virus (HIV) infection. Twenty-three eyes of 15 HIV-negative patients diagnosed with CMV retinitis were included in this retrospective study. The median follow-up was 68 weeks (range, 12-156), and median number of injections was 10 (range, 2-22). The retinal lesions stopped progressing within 1-2 weeks following treatment. All of the eyes showed either unchanged or ≥2 line improvements of BCVA at last visit. There was no development of CMV retinitis in a fellow eye, or recurrence in a studied eye. Systemic complications such as neutropenia were not detected. Intravitreal ganciclovir injections combined with systemic anti-viral treatment is a good therapeutic option for treating CMV retinitis without HIV infection. Such treatment provided favorable visual outcomes, with minimal ocular and systemic complications.

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Citations

Jul 26, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maroun Sfeir
Oct 17, 2015·Ocular Immunology and Inflammation·Emmett T CunninghamManfred Zierhut
Mar 20, 2019·Current Ophthalmology Reports·Alexander D PortMrinali P Gupta
Jan 8, 2020·Microorganisms·Monique MunroAnn-Marie Lobo-Chan
Nov 14, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kayo SuzukiSusumu Ishida
Apr 23, 2021·International Ophthalmology·Muhammed Talha SadikIlknur Tugal-Tutkun

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