Cytomegalovirus Shedding in Seropositive Pregnant Women From a High-Seroprevalence Population: The Brazilian Cytomegalovirus Hearing and Maternal Secondary Infection Study

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Nayara G BarbosaM M Mussi-Pinhata

Abstract

Most congenital cytomegalovirus (CMV) infections in highly seropositive populations occur in infants born to women with preexisting CMV seroimmunity. Although essential for developing prevention strategies, CMV shedding patterns in pregnant women with nonprimary infections have not been characterized. We investigated correlates of CMV shedding in a cohort of seropositive pregnant women. In a prospective study, saliva, urine, vaginal swabs, and blood were collected from 120 CMV-seropositive women in the first, second, and third trimesters and 1 month postpartum. Specimens were tested for CMV DNA by polymerase chain reaction. We analyzed the contribution of the specific maternal characteristics to viral shedding. CMV shedding was detected at least once in 42 (35%) women. Mothers living with or providing daily care to young children (3-6 years) were twice as likely to shed CMV at least once compared to women with less exposure to young children (58% vs 26%; adjusted relative risk [aRR], 2.21; 95% confidence interval [CI], 1.37-3.56). Living in crowded households (≥2 people per room) was associated with viral shedding (64% vs 31%; aRR, 1.99; 95% CI, 1.26-3.13). Sexual activity as indicated by the number of sexual partners per year ...Continue Reading

References

Aug 1, 1985·The Journal of Infectious Diseases·S H ChandlerK K Holmes
May 29, 1986·The New England Journal of Medicine·R F PassG A Cloud
Jun 1, 1993·Journal of Clinical Microbiology·C Y ShenC W Wu
May 9, 1998·Revista Da Sociedade Brasileira De Medicina Tropical·A Y YamamotoM M Mussi-Pinhata
Aug 7, 1999·The Journal of Infectious Diseases·F ZanghelliniR F Pass
May 3, 2001·The New England Journal of Medicine·S B BoppanaW J Britt
Oct 20, 2005·The Journal of Infectious Diseases·Shannon A RossAnd Suresh Boppana
Jan 25, 2008·Journal of Clinical Microbiology·Zdenek NovakSuresh B Boppana
Apr 22, 2008·The Journal of Infectious Diseases·Steve KayeArnaud Marchant
Jul 9, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marisa M Mussi-PinhataWilliam J Britt
Jan 12, 2010·American Journal of Obstetrics and Gynecology·Aparecida Yulie YamamotoWilliam J Britt
Nov 6, 2010·The Journal of Infectious Diseases·Nitin AroraShannon A Ross
Mar 12, 2011·Journal of Medical Microbiology·Ashley L SchoenfischMichael J Cannon
Jun 16, 2011·Reviews in Medical Virology·Michael J CannonD Scott Schmid
Apr 3, 2012·Preventive Medicine·Michael J CannonRobert F Pass
Jan 9, 2013·Clinical Microbiology Reviews·Sheetal ManicklalRavindra K Gupta
Apr 5, 2013·Acta Obstetricia Et Gynecologica Scandinavica·Matilda BerntssonTomas Bergström
Dec 3, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maria Grazia RevelloGiuseppe Gerna

❮ Previous
Next ❯

Citations

Dec 6, 2019·Prenatal Diagnosis·Mariana C DiogoDaniela Prayer
Oct 22, 2019·AIDS·Peter A BarryDennis J Hartigan-O'Connor
Mar 7, 2020·The Journal of Infectious Diseases·Marisa Marcia Mussi-Pinhata, Aparecida Yulie Yamamoto
Feb 10, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey R DorfmanPenny L Moore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.