Cytomorphologic patterns of Pap and PAS-stained oral exfoliative cytology smears in adult Saudi diabetic patients as compared to healthy controls

Diagnostic Cytopathology
Magdi Mansour SalihAfaf Abd El-Hafez

Abstract

Diabetes mellitus (DM) is one of the most common metabolic disorders worldwide and 425 million people were estimated to have diabetes by 2017. Oral manifestations reflect the metabolic control of diabetes. Exfoliative cytology using Papanicolaou (Pap) and periodic acid Schiff (PAS) stains is a practical technique to evaluate oral epithelial cytomorphologic changes in diabetes. This study analyzes the cytomorphologic changes and the glycogen content in exfoliated oral epithelial cells among diabetic patients as compared to healthy controls using Pap and PAS stains to verify the utility of exfoliative cytology as adjunct to diagnosis, follow up or screening of diabetes. Eighty-nine participants; 38 adult diabetic patients (case group) and 51 age-matching nondiabetics (control group) were enrolled in the study after fulfilling appropriate inclusion and exclusion criteria. Sampling and staining procedures were performed using routine protocols. Slides were observed by two pathologists and categorized as inflammatory, dyskaryotic and negative. Glycogen content was expressed as PAS negative or +, ++, and +++ positive. The difference between the diabetics and the controls was statistically significant regarding inflammatory, dyskaryot...Continue Reading

References

Jul 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Saoussen Bamri-EzzineMoïse Bendayan
Aug 9, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Thomas Beikler, Thomas F Flemmig
Sep 13, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sandra AlbertiLuís A A Taveira
Sep 27, 2008·Journal of Oral Science·Hassan Hosseinpour JajarmAfsaneh Rangiani
Nov 10, 2009·Diabetes Research and Clinical Practice·J E ShawP Z Zimmet
Feb 26, 2010·Diabetology & Metabolic Syndrome·Carlos Antonio Negrato, Olinda Tarzia
Aug 21, 2012·The Medical Journal of Australia·Michael C d'EmdenUNKNOWN Australasian Association of Clinical Biochemists
Jun 11, 2014·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Krzysztofa KazanowskaMałgorzata Radwan-Oczko
Nov 26, 2015·Journal of Oral and Maxillofacial Pathology : JOMFP·Bhagyashri R LattiRamchandra G Latti
Sep 22, 2017·Journal of Oral and Maxillofacial Pathology : JOMFP·Manisha SahuPramod Kumar

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Citations

Aug 22, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Srijayaprakash B UppadaSiddappa N Byrareddy

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