Abstract
Primary non-Hodgkin's lymphoma of the central nervous system (PCNSL) has recently increased in incidence, due primarily to an enlarging immunosuppressed patient population. The pathogenetic role of Epstein-Barr virus (EBV) is of interest due to its established role in other lymphoproliferative disorders in immunosuppressed patients. Twenty-three cases of histologically confirmed PCNSL with corresponding cytology were identified, all obtained under stereotactic guidance. Twenty patients were human immunodeficiency virus (HIV) positive, two were HIV negative, and one was of unknown status. Papanicolaou-stained slides were selected from each case and evaluated for the presence of EBV RNA via in situ hybridization (ISH) utilizing a biotinylated probe specific for EBER 1 RNA, and detected by a conventional streptavidin-peroxidase system. The cases included immunoblastic (12), large cell (10), and mixed small and large cell lymphoma (1). The predominant immunophenotype was B-cell (19), although T-cell (2) and biphenotypic (1) cases were also identified. ISH showed nuclear positivity for EBV RNA in 19 of 23 cases (83%). This study confirms the presence of EBV in PCNSL in immunosuppressed patients and implies a potential etiologic role...Continue Reading
References
Sep 15, 1992·Cancer·L M DeAngelisH Furneaux
Oct 19, 1991·Lancet·E M MacMahonR F Ambinder
Jan 1, 1990·Baillière's Clinical Haematology·L D Kaplan
Jun 1, 1989·Neurology·R M BashirR M Singer
Apr 1, 1989·American Journal of Clinical Oncology·T H GroteD H Johnson
Oct 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A F ListL B Vogler
Nov 1, 1985·The Journal of Infectious Diseases·M HoR L Hardesty
Dec 1, 1988·Cancer·N L EbyP C Burger
Jun 1, 1988·Journal of Neurosurgery·F H Hochberg, D C Miller
Nov 1, 1986·Annals of Neurology·Y T SoR L Davis
Nov 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M NonoyamaS Singh
Jan 1, 1972·Cancer·C FreemanS J Cutler
Apr 15, 1983·Virology·D J BrigatiD C Ward
Sep 1, 1983·Annals of Surgery·D W HantoJ S Najarian
Jan 6, 1983·The New England Journal of Medicine·W D SniderS L Nielsen
Jan 1, 1995·Leukemia & Lymphoma·A M Hernandez, D Shibata
Mar 1, 1995·American Journal of Clinical Pathology·J C IezzoniL M Weiss
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A M Levine
Dec 1, 1993·Annals of Internal Medicine·H A Fine, R J Mayer
Citations
Jul 8, 2009·Infectious Agents and Cancer·Brady BeltranJorge Castillo
Nov 21, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Delphine RaouxMichel Péoc'h
Oct 22, 2013·G3 : Genes - Genomes - Genetics·Jennifer HardeeMichael Snyder
Feb 25, 1999·Journal of Pediatric Hematology/oncology·H C RossbachJ L Barbosa
Oct 27, 1999·Journal of Pineal Research·M VicianP Matis
Mar 2, 2013·Expert Review of Neurotherapeutics·Julia PakpoorSreeram V Ramagopalan
Oct 8, 2021·Seminars in Neurology·Anastasia Vishnevetsky, Pria Anand