Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance

Annals of Hematology
Louise de SwartUlrich Germing

Abstract

The European LeukemiaNet MDS (EUMDS) registry is collecting data of myelodysplastic syndrome (MDS) patients belonging to the IPSS low or intermediate-1 category, newly diagnosed by local cytologists. The diagnosis of MDS can be challenging, and some data report inter-observer variability with regard to the assessment of the MDS subtype. In order to ensure that correct diagnoses were made by the participating centres, blood and bone marrow slides of 10% of the first 1000 patients were reviewed by an 11-person panel of cytomorphologists. All slides were rated by at least 3 panel members (median 8 panel members; range 3-9). Marrow slides from 98 out of 105 patients were of good quality and therefore could be rated properly according to the WHO 2001 classification, including assessment of dysplastic lineages. The agreement between the reviewers whether the diagnosis was MDS or non-MDS was strong with an intra-class correlation coefficient (ICC) of 0.85. Six cases were detected not to fit the entry criteria of the registry, because they were diagnosed uniformly as CMML or AML by the panel members. The agreement by WHO 2001 classification was strong as well (ICC = 0.83). The concordance of the assessment of dysplastic lineages was su...Continue Reading

References

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Jul 3, 2013·Haematologica·Fernando Ramos, Silvia Fernández-Ferrero
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Citations

Aug 22, 2018·Blood Advances·Raphael ItzyksonUNKNOWN European MDS Registry members
Aug 20, 2017·Current Hematologic Malignancy Reports·Aaron C Shaver, Adam C Seegmiller
Mar 13, 2020·Nature Medicine·Albert G TsaiSean C Bendall
Jun 28, 2018·Leukemia·Ghulam J MuftiRobert P Hasserjian

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Methods Mentioned

BETA
MDS
biopsy
flow cytometry

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