Cytopathologic analysis of thyroid lesions in the pediatric population

Diagnostic Cytopathology
Gregory A HoslerSyed Z Ali

Abstract

Fine-needle aspiration (FNA) of the thyroid is seldom performed in the pediatric population. Therefore, the clinical utility of thyroid FNA in this patient group has not been adequately addressed. A 15 yr retrospective review of the cytopathology archives at the participating institutions was performed to identify cases of thyroid FNA performed in pediatric patients. The medical records of these cases were reviewed, including the surgical pathology reports of those patients who had subsequently undergone surgical resection. One hundred one specimens from 82 patients were identified. Of these, 40 had a cytopathologic diagnosis of carcinoma, "suspicious" for carcinoma, neoplasm, or atypia, 48 were benign, and 13 were unsatisfactory. Of the 82 patients, 45 underwent partial or total thyroidectomy. Twenty-two (49%) of these were found to harbor a malignant neoplasm (18 papillary carcinomas). The diagnostic sensitivity for identifying a lesion was 87% (26/30) and the diagnostic specificity was 92% (47/51). There were four false-positives and four false-negatives in the review, yielding a positive predictive value of 87% and a negative predictive value of 92%. We conclude that FNA is a useful adjunct to the management of thyroid lesi...Continue Reading

References

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Citations

May 19, 2009·Thyroid : Official Journal of the American Thyroid Association·Roberto IzquierdoKamal Khurana
Jun 22, 2011·Applied Immunohistochemistry & Molecular Morphology : AIMM·Soheir Mohamed MahfouzReham Shehab El-Nemr
Jun 26, 2007·Journal of Medical Case Reports·Joshua P Klopper, Michael T McDermott
Jan 22, 2010·World Journal of Surgery·Anna E BargrenStan B Sidhu
Dec 1, 2009·Journal of Pediatric Surgery·Christopher StevensGeoffrey K Blair
Jul 7, 2009·The Journal of Surgical Research·Anna E BargrenHerbert Chen
Dec 21, 2011·Pediatric Blood & Cancer·Antje RedlichPeter Vorwerk
Mar 13, 2016·Cancer Cytopathology·Kristen L PartykaHoward H Wu
Jul 15, 2016·Cancer Cytopathology·Elmira AmirazodiJonathan D Wasserman
May 17, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·D C MalheirosF Schmitt
Feb 16, 2019·Cancer Cytopathology·Huiying WangVivian L Weiss
Mar 15, 2015·Indian Journal of Surgical Oncology·B N GayathriS M Azeem Mohiyuddin
Jun 6, 2017·Cancer Cytopathology·Esther Diana RossiLuigi Maria Larocca

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