Cytopathologic grading of hepatocellular carcinoma on fine-needle aspiration

Cancer
Piotr KuleszaSyed Z Ali

Abstract

Hepatocellular carcinoma (HCC) is routinely graded histopathologically using a modified Edmondson system (ES). The cytologic grading of HCC has been used predominantly as an adjunct in differential diagnoses (i.e., to help distinguish HCC from other tumors as well as nonneoplastic lesions). However, there are unanswered questions regarding the reliability of the cytologic grading of HCC and its correlation with histologic follow-up. A total of 106 cases of HCC were identified in the authors' cytopathology files from 1977 to the present. Of these cases, 64 had either a core needle or excisional biopsy sample that was judged to be adequate for histologic grading. From each case smears were graded independently in a blinded fashion by two cytopathologists, and tissue slides were graded by a liver pathologist. The cytopathologists' grading was then adjudicated by considering the histologic diagnosis as the "truth standard". Finally, after the scores were calculated, a statistical analysis was performed to ascertain the accuracy of the cytopathologic grading. The sensitivity for accurate grading was found to be highest for well differentiated (WD) lesions; the specificity was found to be highest for poorly differentiated (PD) HCC fo...Continue Reading

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Citations

Jan 18, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Abraham JacobLong-Sheng Chang
May 24, 2012·Veterinary Clinical Pathology·Carlo Masserdotti, Michele Drigo
Jun 9, 2006·Diagnostic Pathology·A BuhmeidaY Collan
Jul 20, 2010·The Surgical Clinics of North America·Cherif BoutrosN Joseph Espat
Jan 13, 2016·World Journal of Gastroenterology : WJG·Umberto CilloAlessandro Vitale

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