Cytopathology of malignant mesothelioma. Reappraisal of the diagnostic value of collagen cores

Cytopathology : Official Journal of the British Society for Clinical Cytology
M DelahayeT H van der Kwast

Abstract

The identification of malignant mesothelial cells in cytological smears prepared from serous effusions is still hampered by the lack of features specific for mesothelial differentiation. We examined the diagnostic value of collagen cores within clusters of tumour cells in cytological smears prepared from effusions from 43 patients with malignant mesothelioma and of 62 cases of metastatic adenocarcinoma. In Giemsa-stained smears collagen cores were detected in 51% of the cases of malignant mesothelioma and in none of the smears with metastatic adenocarcinoma. Using the Azan stain, collagen cores were detected in 64% of the malignant mesotheliomas and 4% of the adenocarcinomas. Immunoelectron microscopy demonstrated that the collagen cores are largely composed of collagen type III fibrils and some elastin embedded in a homogenous extracellular matrix. It can be concluded that the presence of collagen cores within clusters of tumour cells is highly suggestive of mesothelial differentiation and a common finding in malignant mesothelioma.

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Citations

Jan 1, 1992·Diagnostic Cytopathology·M W StevensD W Henderson
Feb 1, 1997·Critical Reviews in Oncology/hematology·H C HoogstedenT van Gelder
Aug 27, 2005·American Journal of Respiratory Cell and Molecular Biology·Ki-Up KimV Courtney Broaddus
May 31, 2008·American Journal of Respiratory Cell and Molecular Biology·Shannon M WilsonV Courtney Broaddus
Jul 6, 2000·Cytopathology : Official Journal of the British Society for Clinical Cytology·D Whitaker
Oct 1, 1991·The Journal of Pathology·M DelahayeT H Van der Kwast
Mar 5, 2016·Cytopathology : Official Journal of the British Society for Clinical Cytology·D DamianiP Vielh
Apr 10, 2007·Diagnostic Cytopathology·Umesh Kapur, Eva M Wojcik
Jun 4, 2021·The Journal of Veterinary Medical Science·Yuuto KawashimaKoichi Kadota

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