PMID: 7026578Sep 1, 1981Paper

Cytoplasmic actin in postsynaptic structures at the neuromuscular junction

The Journal of Cell Biology
Z W HallJ H Schwartz

Abstract

We used an antibody prepared against Aplysia (mollusc) body-wall actin that specifically reacts with certain forms of cytoplasmic actin in mammalian cells to probe for the presence of actin at the neuromuscular junction. Immunocytochemical studies showed that actin or an actinlike molecule is concentrated at neuromuscular junctions of normal and denervated adult rat muscle fibers. Actin is present at the neuromuscular junctions of fibers of developing diaphragm muscles as early as embryonic day 18, well before postsynaptic folds are formed. These results suggest that cytoplasmic actin may play a role in the clustering or stabilization of acetylcholine receptors at the neuromuscular junction.

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Citations

Jul 13, 2000·Cell Motility and the Cytoskeleton·C A Moores, J Kendrick-Jones
Jan 1, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Joe V Chakkalakal, Bernard J Jasmin
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Feb 1, 1984·The Journal of Cell Biology·S BursztajnS H Appel

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