Cytoplasmic antigen in hepatocytes of chimpanzees infected with non-A, non-B hepatitis virus or hepatitis delta virus: relationship to interferon.

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Y K Shimizu, R H Purcell

Abstract

We previously described a cytoplasmic antigen, detected by monoclonal antibodies, in hepatocytes of chimpanzees experimentally infected with the parenterally transmitted form of non-A, non-B hepatitis virus or with the hepatitis delta virus. The expression of this antigen appears to be a host-specified response to infection with these two hepatitis viruses but not with hepatitis A virus, hepatitis B virus or enterically transmitted non-A, non-B hepatitis virus. To determine whether this antigen, found in parallel with the hepatocyte cytoplasmic structures described previously, is associated with interferon, as suggested by others, we studied by immunofluorescence liver biopsies from chimpanzees treated with an interferon inducer or exogenous interferon for the presence of the antigen. In two hepatitis B virus carrier chimpanzees and one normal chimpanzee treated with the interferon inducer polyinosinic-polyribocytidylic acid-poly-l-lysine carboxymethylcellulose, the antigen became detectable in hepatocytes within 2 weeks of initiation of the treatment, remained detectable throughout the treatment and disappeared within 4 weeks after treatment was terminated. Electron microscopy revealed that the biopsies positive for the antige...Continue Reading

References

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Citations

Jan 1, 1991·Archives of Virology·P G Plagemann
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y K ShimizuR H Purcell
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y K ShimizuH Yoshikura
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·R H Purcell
Jan 1, 1996·Journal of Viral Hepatitis·H YoshikuraY K Shimizu
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F NegroF Bonino
Jun 19, 2015·Virology·L M R El-AttarJ Brownlie

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