Cytoplasmic body myopathy masquerading as motor neuron disease

Muscle & Nerve
Arun V KrishnanMatthew C Kiernan

Abstract

Cytoplasmic body myopathy (CBM) is characterized by proteinaceous inclusion bodies in muscle tissue. A 43-year-old woman presented with rapidly progressive weakness and dysphagia. Electromyography (EMG) elsewhere demonstrated lower-limb chronic partial denervation. Muscle biopsy showed fiber size variation without diagnostic features. A diagnosis of possible motor neuron disease was made and the patient was commenced on riluzole. Subsequently, the patient's condition stabilized, prompting reassessment. Repeat EMG demonstrated no features of denervation and was more suggestive of a myopathic process. Review of the original muscle biopsy showed cytoplasmic bodies. The case highlights a further diagnostic possibility in the assessment of patients with "possible" motor neuron disease. The clinical features of CBM are briefly reviewed.

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Citations

Jan 18, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Margie C ZoingMatthew C Kiernan
Mar 22, 2005·Lancet Neurology·Jennica M C WinhammarMatthew C Kiernan
May 15, 2010·Infectious Disease Clinics of North America·Patricia MuñozEmilio Bouza

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