Cytoplasmic c-ros oncogene 1 receptor tyrosine kinase expression may be associated with the development of human oral squamous cell carcinoma

Oncology Letters
Yong ChengXiaojun Ding

Abstract

The c-ros oncogene 1 receptor tyrosine kinase (ROS1) gene encodes a proto-oncogenic protein that has been demonstrated to be involved in the pathogenesis of several types of cancer. The present study aimed to analyze the expression of ROS1 in human oral squamous cell carcinomas (OSCCs), and investigate the association between its expression and the clinicopathological parameters of patients with OSCC. Paraffin-embedded OSCC tissues from 31 patients were obtained and the expression of ROS1 was analyzed by immunohistochemistry. The cellular location of ROS1 was determined by immunofluorescence in human oral cancer CAL-27 cells. The association of clinicopathological characteristics and survival rates with ROS1 expression were assessed. The results revealed that ROS1 was exclusively localized in the cytoplasm of the OSCC tissues (24/30, 80.0%), and in the cytoplasm of adjacent dysplastic epithelial tissues (2/15, 13.3%) (P<0.001). The moderate to strong expression of ROS1 in the cytoplasm was higher in OSCC tissues than in the normal epithelial tissues adjacent to the tumor (67.7 vs. 0%, P=0.001). The results of the Kaplan-Meier analysis and multivariate Cox regression analysis indicated that there was no association between the 5...Continue Reading

References

May 1, 1992·Head & Neck·N J RolandP M Stell
May 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D SmithB G Haffty
May 18, 2001·Nature·P Blume-Jensen, T Hunter
Jan 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Alan CharestDavid Housman
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johanna MrenaCaj Haglund
Oct 29, 2005·Journal of Clinical Pathology·J LimS-P Hong
Aug 5, 2008·Oral Oncology·Stefano Petti
Mar 3, 2009·Oral Oncology·Crispian Scully, Jose Bagan
Nov 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Banibrata SenFaye M Johnson
Jan 5, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristin BergethonA John Iafrate
Jan 14, 2012·Oral Oncology·Avaniyapuram Kannan MuruganNobuo Tsuchida
Apr 25, 2012·Journal of Oral and Maxillofacial Pathology : JOMFP·M AkhterMotiur R Molla
Jun 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Victoria M RimkunasHerbert Haack
Apr 4, 2013·Yonsei Medical Journal·Minseob EomKwang Hwa Park
May 31, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kurtis D Davies, Robert C Doebele
Jun 13, 2014·International Journal of Cancer. Journal International Du Cancer·Colleen WebberPatti A Groome

Citations

Feb 1, 2019·Journal of Experimental & Clinical Cancer Research : CR·Yingqiu XieZhenbang Chen

Related Concepts

Malignant Neoplasms
Cytoplasm
Genes
Immunohistochemistry
Neoplasms
Regression Analysis
Immunofluorescence Assay
Oral Cavity Carcinoma
Adjacent
Local

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Related Papers

The British Journal of Oral & Maxillofacial Surgery
Masaru SugiyamaNobuyuki Kamata
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Lukman Bin Md AuzairRosnah Binti Zain
© 2021 Meta ULC. All rights reserved