Cytoplasmic Control of Sense-Antisense mRNA Pairs

Cell Reports
Flore SinturelLionel Benard

Abstract

Transcriptome analyses have revealed that convergent gene transcription can produce many 3'-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3'-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 3'-overlapping messengers or their impact on gene expression. Here, we demonstrate that the complementary tails of 3'-overlapping mRNAs can interact in the cytoplasm and promote post-transcriptional regulatory events including no-go decay (NGD) in Saccharomyces cerevisiae. Genome-wide experiments confirm that these messenger-interacting mRNAs (mimRNAs) form RNA duplexes in wild-type cells and thus have potential roles in modulating the mRNA levels of their convergent gene pattern under different growth conditions. We show that the post-transcriptional fate of hundreds of mimRNAs is controlled by Xrn1, revealing the extent to which this conserved 5'-3' cytoplasmic exoribonuclease plays an unexpected but key role in the post-transcriptional control of convergent gene expression.

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Citations

May 28, 2016·Current Genetics·Alvaro de Andres-PabloMaxime Wery
Feb 22, 2018·Autophagy·Elizabeth Delorme-AxfordDaniel J Klionsky
Jan 9, 2020·Nature Communications·Albertas NavickasLionel Benard
Oct 4, 2019·Molecular Biology and Evolution·Jules GiletIngrid Lafontaine
Feb 14, 2019·Scientific Reports·Pascale JolivetMaria Teresa Teixeira
Dec 16, 2017·International Journal of Molecular Sciences·Takeo Wada, Attila Becskei
Mar 23, 2019·Nature Communications·Bernat Blasco-MorenoJuana Díez

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