Cytoplasmic dynein: tension generation on microtubules and the nucleus

Cellular and Molecular Bioengineering
Nandini ShekharTanmay P Lele

Abstract

Cytoplasmic dynein is a microtubule dependent motor protein that is central to vesicle transport, cell division and organelle positioning. Recent studies suggest that dynein can generate significant pulling forces on intracellular structures as it motors along microtubules. In this review, we discuss how dynein-generated pulling forces position the nucleus and the centrosome.

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Related Concepts

Cell Division
Cell Nucleus
Microtubules
Intracellular
Centrosome
Positioning Attribute
Cytoplasmic Dyneins
Vesicle-mediated Transport
Study

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