Cytoplasmic expression of estrogen receptor β may predict poor outcome of EGFR-TKI therapy in metastatic lung adenocarcinoma

Oncology Letters
Xiaosheng DingJun Liang

Abstract

There is growing evidence that estrogen receptors (ER) are expressed in lung cancer cells, and are able to interact with the epidermal growth factor receptor (EGFR) signaling pathway. However, data on the association between cytoplasmic ER expression and the response to EGFR-tyrosine kinase inhibitors (TKI) treatment are limited. The aim of the present study was to investigate the associations between ERα/ERβ expression and EGFR mutational status and response to TKI treatment in metastatic lung adenocarcinoma. A retrospective study of 126 consecutive patients with lung adenocarcinoma who were diagnosed with stage IV disease and had received EGFR-TKI treatment was conducted. ER expression was detected by immunohistochemistry. EGFR and GTPase KRas (KRAS) mutational statuses were evaluated by denaturing high performance liquid chromatography and PCR-restriction fragment length polymorphism, respectively. In the overall cohort of 126 lung adenocarcinoma samples analyzed, ERα expression in the nucleus of tumor cells was identified in 17 (18.9%) patients, whereas ERβ expression was identified in the nucleus (22/126, 17.5%) and cytoplasm (17/126, 13.5%). The nuclear expression of ERβ was positively associated with the degree of tumor ...Continue Reading

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Citations

Apr 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xu ZhaoSinuan Chen
Nov 17, 2020·Frontiers in Oncology·Rahul MalMathew A Cherian
Jun 4, 2021·Frontiers in Medicine·Vianey Rodriguez-Lara, Maria Rosa Avila-Costa

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Methods Mentioned

BETA
hormone replacement therapy
biopsy
GTPase

Clinical Trials Mentioned

NCT00100854
NCT01556191

Software Mentioned

SPSS

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