Cytoplasmic Listeria monocytogenes stimulates IFN-beta synthesis without requiring the adapter protein MAVS.

FEBS Letters
Didier SoulatThomas Decker

Abstract

The mitochondria-associated adapter protein MAVS (also called IPS-1, VISA or CARDIF, designated MAVS for reasons of simplicity in our manuscript) relays signals from cytoplasmic sensors of viral RNA to the IRF3 kinase complex and the interferon-beta (IFN-beta) gene. Using siRNA-mediated knock-down in macrophages we show that IFN-beta synthesis in response to transfected, intracellular double-stranded RNA (dsRNA), a pathogen-associated molecular pattern of viruses, is decreased in absence of MAVS. By contrast, the Gram-positive bacterium Listeria monocytogenes targets the IFN-beta gene without detectable MAVS requirement. The data show that MAVS is not a central adapter protein for all cytoplasmic pathogen sensors that stimulate IFN-beta synthesis.

References

Oct 1, 1996·Genome Research·C A HeidP M Williams
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·David E Levy, J E Darnell
Oct 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mary O'RiordanDaniel A Portnoy
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvia StockingerThomas Decker
Aug 28, 2003·Nature Cell Biology·Carol A SledzBryan R G Williams
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Nov 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·J AndrejevaR E Randall
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvia StockingerThomas Decker
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan M O'ConnellGenhong Cheng
Jun 22, 2005·Trends in Immunology·Fabio Martinon, Jürg Tschopp
Aug 13, 2005·Trends in Molecular Medicine·Caroline A Jefferies, Katherine A Fitzgerald
Aug 20, 2005·Nature Reviews. Immunology·Thomas DeckerSilvia Stockinger
Aug 30, 2005·Nature Immunology·Taro KawaiShizuo Akira
Sep 13, 2005·Molecular Cell·Liang-Guo XuHong-Bing Shu
Oct 11, 2005·International Immunology·Kenya HondaTadatsugu Taniguchi
Dec 17, 2005·Nature Immunology·Stefan Bauer
Jan 18, 2006·Immunity·Daniel B Stetson, Ruslan Medzhitov

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Citations

Jul 31, 2013·Immunobiology·Martin Schlee
Jul 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gregory T CrimminsDaniel A Portnoy
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Fabrizia StavruPascale Cossart
Apr 16, 2009·Clinical Microbiology Reviews·Trine H Mogensen
Jan 16, 2008·PLoS Pathogens·Jess H LeberDaniel A Portnoy
Feb 11, 2012·Critical Reviews in Immunology·Uma Nagarajan
Jan 10, 2008·Cellular Microbiology·Benjamin ReuttererThomas Decker
Feb 26, 2011·Immunological Reviews·Fabrizia StavruPascale Cossart
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrick PaladinoKaren L Mossman
Jan 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel PrantnerUma M Nagarajan
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne-Danielle C ChesslerBarbara A Burleigh
Oct 7, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas M Petro
May 28, 2019·Microbiology Spectrum·Sarah E F D'Orazio
Aug 28, 2007·Microbes and Infection·Lauren A Zenewicz, Hao Shen

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