Cytoplasmic phospholipase A₂ modulation of adolescent rat ethanol-induced protein kinase C translocation and behavior

Neurochemical Research
J L SanterreD F Werner

Abstract

Ethanol consumption typically begins during adolescence, a developmental period which exhibits many age-dependent differences in ethanol behavioral sensitivity. Protein kinase C (PKC) activity is largely implicated in ethanol-behaviors, and our previous work indicates that regulation of novel PKC isoforms likely contributes to decreased high-dose ethanol sensitivity during adolescence. The cytoplasmic Phospholipase A2 (cPLA2) signaling cascade selectivity modulates novel and atypical PKC isoform activity, as well as adolescent ethanol hypnotic sensitivity. Therefore, the current study was designed to ascertain adolescent cPLA2 activity both basally and in response to ethanol, as well as it's involvement in ethanol-induced PKC isoform translocation patterns. cPLA2 expression was elevated during adolescence, and activity was increased only in adolescents following high-dose ethanol administration. Novel, but not atypical PKC isoforms translocate to cytosolic regions following high-dose ethanol administration. Inhibiting cPLA2 with AACOCF3 blocked ethanol-induced PKC cytosolic translocation. Finally, inhibition of novel, but not atypical, PKC isoforms when cPLA2 activity was elevated, modulated adolescent high-dose ethanol-sensiti...Continue Reading

References

Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D FerrisS H Snyder
Jul 1, 1990·Environmental Health Perspectives·N P Franks, W R Lieb
Mar 26, 1998·Biochemical Pharmacology·B S BasavarajappaB L Hungund
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·M M Silveri, L P Spear
Jul 18, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·S UmarA P Morris
Apr 12, 2003·Psychoneuroendocrinology·A BartolomucciS Parmigiani
Aug 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rachel BrightDaria Mochly-Rosen
Aug 12, 2004·Biological & Pharmaceutical Bulletin·Tetsuya HirabayashiTakao Shimizu
Aug 26, 2006·Science·Eva PastalkovaTodd Charlton Sacktor
Aug 19, 2007·Trends in Pharmacological Sciences·Stephen P Soltoff
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Doo-Sup ChoiRobert O Messing
Jul 7, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Andreia Oliveira-da-SilvaYael Abreu-Villaça
Aug 25, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Meng ZhaoGuo-Qiang Chen
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melissa A HermanMarisa Roberto
Aug 6, 2013·Alcoholism, Clinical and Experimental Research·Kwan-Hoon MoonMichael A Collins
Aug 29, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Antonella Macerollo, Graziella Quattrocchi

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.