PMID: 6166854May 22, 1981Paper

Cytoplasmic processing events in the polyadenylate region of Physarum messenger RNA

Molecular Biology Reports
W R JefferyD Noonan

Abstract

Cytoplasmic processing events in the poly(A) region of mRNA from Physarum polycephalum are reviewed. Two classes of poly-containing RNA [poly(A)+ RNA] exist in the cytoplasm. One contains very short poly(A) sequences, averaging about 15 adenylate residues, while the other contains relatively long poly(A) sequences, averaging about 60 residues. Molecules with short poly(A) sequences are found exclusively in the polysomes while those with long poly(A) sequences are restricted to the free cytoplasmic mRNP. Since proteins are associated with only the long poly(A) sequences the poly(A) . protein complex is also restricted to the free mRNP. The long poly(A) sequences are relatively short-lived. They are degraded by two distinct processes, a shortening process in which 15-20 residues are gradually removed and a turnover process in which long poly(A) tracts are rapidly converted to the short sequences. This process, along with the dissociation of the poly(A) . protein complex, occurs when poly(A)+ RNA molecules located in free mRNP are transferred to the polysomes. Poly(A) . protein complex dissociation appears to precede poly(A) turnover during translational selection. The significance of these processing events in relation to mRNA ma...Continue Reading

References

Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M B DworkinA A Infante
Jan 1, 1978·Progress in Nucleic Acid Research and Molecular Biology·A A Preobrazhensky, A S Spirin
May 31, 1979·Molecular Biology Reports·H M PrincenW J van Venrooij
Jan 1, 1979·Progress in Nucleic Acid Research and Molecular Biology·J E Darnell
Sep 16, 1976·Nature·N J Proudfoot, G G Brownlee
Dec 1, 1976·Archives of Biochemistry and Biophysics·A J JaworskiO M Bateman
Dec 1, 1976·Cell·A J Shatkin
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·D SheinessJ E Darnell
Nov 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·S W Kwan, G Brawerman
Feb 28, 1973·Nature: New Biology·D Sheiness, J E Darnell
May 8, 1969·Biochemical and Biophysical Research Communications·W SchiebelH P Rusch
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D S AdamsW R Jeffery

❮ Previous
Next ❯

Citations

Jan 1, 1987·Molecular Biology Reports·C M Tsiapalis
Jan 1, 1984·Acta Oto-laryngologica. Supplementum·L SchalénN Henriksson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
J M Caron, M W Kirschner
Proceedings of the National Academy of Sciences of the United States of America
T G LafflerW F Dove
Proceedings of the National Academy of Sciences of the United States of America
G HuezY Cleuter
© 2021 Meta ULC. All rights reserved