Cytoplasmic receptors for 17 beta-estradiol, 5 alpha-dihydrotestosterone and progesterone in normal and abnormal human uterine tissues

Cancer Letters
S GrilliG Prodi

Abstract

Determinations of specific cytoplasmic receptors for 17 beta-estradiol (E), 5 alpha-dihydrotestosterone (DHT) and progesterone (P) in normal and abnormal endometrium are reported. The standardization of methodology with particular emphasis on specificity trials is outlined. Receptors were present in all but one case, a moderately differentiated endometrial adenocarcinoma. Generally speaking, steroid and peptide hormone plasma content in patients with malignant conditions were at the lower limit values of normal, except for follicle-stimulating hormone which had values significantly higher than normal. The question of E competition with DHT in binding DHT-receptor and the therapeutic implications of P-receptor estimation are discussed.

References

Jan 1, 1987·Endocrine Research·E K Muechler
Apr 1, 1985·British Journal of Obstetrics and Gynaecology·M A QuinnM Cauchi
Jan 1, 1980·Journal of Cancer Research and Clinical Oncology·G ProdiC Orlandi
Jan 1, 1985·Journal of Receptor Research·H C PotgieterJ J van der Watt
Dec 15, 1989·Cancer·F De Cicco NardoneS Dell'Acqua

Related Concepts

Androgen Receptor
Receptors, Cytoplasmic
Endometrium
Uterus
Protoplasm
Progesterone
Progesterone [EPC]
Progesterone Measurement
Cell Differentiation Process
Postmenopause

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