Cytoplasmic signaling in the control of mitochondrial uproar?

Cell Communication and Signaling : CCS
Martin HermannJakob Troppmair

Abstract

The concept of a pre-emptive strike as a good means to prevent greater harm may be frequently over-stressed in daily life. However, biological systems in a homeostatic balance are prepared to withstand a certain degree of hostile fire by rather passive means. This also applies to the maintenance of cell survival, where a plethora of protective proteins provide safeguard against erroneous activation of death pathways. Apart from these mechanisms active processes are also essential for the maintenance of cellular homeostasis, commonly referred to as survival signaling. Frequently their targets may be mitochondrial, assuring organelle integrity, which is essential for continued energy production and survival. Transient or permanent failures in these cellular defense strategies result in pathophysiological conditions, which manifest themselves e.g. as cancer or ischemia/reperfusion-associated organ damage.

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Citations

Feb 22, 2011·Analytical and Bioanalytical Chemistry·Andrey V KuznetsovJakob Troppmair
Jan 16, 2014·Cell Communication and Signaling : CCS·Muhammad Imtiaz AshrafJakob Troppmair
May 6, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Robert SucherJakob Troppmair
Oct 18, 2011·Journal of Neuroscience Research·Jing ZhuGabriele V Ronnett
May 27, 2009·International Journal of Molecular Sciences·Andrey V Kuznetsov, Raimund Margreiter
Apr 7, 2018·Molecular Oncology·Tobias FurlanJakob Troppmair
Sep 15, 2016·The Journal of Biological Chemistry·Martina HallerJakob Troppmair

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Methods Mentioned

BETA
GTPase
ubiquitination

Software Mentioned

MARCH

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