Abstract
The cytoplasmic staining of thyroid transcription factor (TTF)-1 was analyzed in 86 liver resection specimens, including 40 hepatocellular carcinoma (HCC), 4 metastatic HCC, 20 cholangiocarcinoma, 2 combined hepatocellular-cholangiocarcinoma (CHC), and 20 metastatic carcinoma (MC) specimens with immunohistochemical stains to TTF-1, cytokeratin (CK)19, hepatocyte paraffin 1, alpha-fetoprotein, polyclonal carcinoembryonic antigen, CK7, and CK20. TTF-1 cytoplasmic staining was identified in 93% of HCCs (37/40), 100% of metastatic HCCs (4/4), 10% of cholangiocarcinomas (2/20), and 5% of MCs (1/20). CK19 was positive in all cholangiocarcinomas and MCs but only in 5% of HCCs (2/40) and none of the metastatic HCCs (0/4). TTF-1 cytoplasmic staining positively correlates with differentiation and the trabecular growth pattern of HCC. The results suggest TTF-1 cytoplasmic staining, together with CK19, might serve as a useful marker for the diagnosis of primary and metastatic HCC and for the differential diagnosis of HCC from cholangiocarcinoma and MC. The mechanism of TTF-1 cytoplasmic staining is explored.
References
Sep 1, 1995·Human Pathology·T MaedaM Tsuneyoshi
Feb 1, 1996·Hybridoma·A HolzingerJ A Whitsett
Nov 21, 1998·Histopathology·A S LeongC T Liew
Mar 11, 1999·The New England Journal of Medicine·H B El-Serag, A C Mason
Jun 12, 1999·Pathology International·M TsujiH Mori
Jan 13, 2000·Histopathology·O Kaufmann, M Dietel
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S N AgoffA L Folpe
May 3, 2000·Histopathology·O Kaufmann, M Dietel
Oct 17, 2001·American Journal of Clinical Pathology·J L HechtG S Pinkus
Jun 8, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sean K LauRichard N Eisen
Dec 11, 2002·American Journal of Clinical Pathology·Tad J WieczorekGeraldine S Pinkus
Aug 7, 2003·Cancer Investigation·Andrew X Zhu
Aug 13, 2003·Japanese Journal of Clinical Oncology·Yoshiko YanoMasatoshi Makuuchi
Mar 17, 2004·American Journal of Clinical Pathology·Chin-Chen PanHung Chiang
Citations
Jul 27, 2011·Pathology Research International·Aileen Wee
Jul 31, 2007·Journal of Clinical Pathology·Tony Kiat-Hon LimPuay-Hoon Tan
Feb 5, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lena A KubbaMichael T Deavers
Jun 10, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nafis ShafizadehSanjay Kakar
Feb 1, 2008·Expert Opinion on Medical Diagnostics·Jun-Yi Lei, Jiaoti Huang
May 27, 2014·Experimental Hematology & Oncology·Lanjing ZhangPaul J Zhang
Jul 19, 2011·Cytopathology : Official Journal of the British Society for Clinical Cytology·A Wee
Oct 12, 2013·Histopathology·Yun-Bi NiGary M Tse
Jan 31, 2012·International Journal of Surgery Case Reports·Min Ho ParkJung Han Yoon
May 20, 2014·Human Pathology·Rondell P GrahamBenjamin R Kipp
Apr 7, 2015·Advances in Anatomic Pathology·James R Conner, Jason L Hornick
Jun 13, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·R García-GarzaA Soto-Domínguez
Jan 15, 2014·The American Journal of Surgical Pathology·Lea F SurreyEmma E Furth
May 1, 2021·Diagnostic Cytopathology·Mangesh ChikhaleRamesh Ananthakrishnan