Cytoplasmic tail domain of glycoprotein B is essential for HHV-6 infection

Virology
Nora F MahmoudYasuko Mori

Abstract

Human herpesvirus 6 (HHV-6) glycoprotein B (gB) is an abundantly expressed viral glycoprotein required for viral entry and cell fusion, and is highly conserved among herpesviruses. The present study examined the function of HHV-6 gB cytoplasmic tail domain (CTD). A gB CTD deletion mutant was constructed which, in contrast to its revertant, could not be reconstituted. Moreover, deletion of gB cytoplasmic tail impaired the intracellular transport of gB protein to the trans-Golgi network (TGN). Taken together, these results suggest that gB CTD is critical for HHV-6 propagation and important for intracellular transportation.

References

Mar 1, 1993·The Journal of General Virology·K EllingerB Fleckenstein
Oct 31, 2003·Expert Reviews in Molecular Medicine·S DewhurstN van Loon
Aug 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Erick Lin, Patricia G Spear
Mar 18, 2009·Cellular Microbiology·Yasuko Mori
May 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Huamin TangYasuko Mori
Nov 7, 2013·Archives of Virology·Dharam AblashiTetsushi Yoshikawa
Feb 8, 2014·Virology·Mayuko HayashiYasuko Mori
Jan 14, 2016·Virology·Nora F MahmoudYasuko Mori

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