Cytoprotective activities of hydroxycinnamic acid amides of serotonin against oxidative stress-induced damage in HepG2 and HaCaT cells

Fitoterapia
Jang-Yeol ChoiSeong-Gene Lee

Abstract

Hydroxycinnamic acid amides of serotonin (HCAAS) [caffeoylserotonin (compound 1), p-coumaroylserotonin (compound 2), and feruloylserotonin (compound 3)] are secondary metabolites produced in plants. The aim of this study was to investigate the cytoprotective effects of HCAAS based on intracellular reactive oxygen radical (ROS) generation, lipid peroxidation, protein carbonylation, and phosphorylation of histone H2AX in H(2)O(2) treated-HepG2 and HaCaT cells. We have shown that HCAAS showed various strong antioxidant activities in hydrogen peroxide treated both cell lines, suggesting that these compounds may play as chemotherapeutic agents for preventing or reducing the oxidative stress-induced diseases.

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Citations

Dec 3, 2014·Plant Science : an International Journal of Experimental Plant Biology·Rainer E HäuslerStephan Krueger
Aug 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuzhu HeOk-Joon Kim
Jan 14, 2020·Pakistan Journal of Biological Sciences : PJBS·Doha A MohamedRasha S Mohamed
Nov 7, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marwa RoumaniRomain Larbat

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