PMID: 2119471Jan 1, 1990Paper

Cytoprotective effect of TRK-100, a prostacyclin analogue, against chemical injuries in cultured human vascular endothelial cells

Life Sciences
A SakaiS Nishio

Abstract

We studied the cytoprotective effect of TRK-100, a chemically stable analogue of prostacyclin (PGI2), in the cultured human endothelial cells from umbilical vein. TRK-100 (10 and 100 nM) stimulated significantly proliferation of endothelial cells but did not affect PGI2 production in endothelial cells. Exposure of cultured endothelial cells to homocysteine (2.5 mM) or glucose (50 mM) caused concentration-dependent cytotoxicity, as evidenced by a decrease in number of viable cells. When endothelial cells were treated with TRK-100 simultaneously or prior to, but not after, exposure to injury substances, decreases in viable cell were significantly suppressed. The protective effect of TRK-100 against homocysteine-induced cytotoxicity also appeared in endothelial cells treated with acetylsalicylic acid, suggesting that endogenous PGI2 did not involve in the protective effect of TRK-100.

References

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Citations

Aug 1, 1992·Molecular and Chemical Neuropathology·T HiranoS Nishio
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·Y Uchiyama-TsuyukiS Otomo
Jan 1, 1993·Progress in Lipid Research·M NegishiA Ichikawa
Apr 20, 2001·British Journal of Pharmacology·O A LawlerB T Kinsella
Mar 16, 2002·European Journal of Biochemistry·Sinead M MigginB Therese Kinsella
Sep 13, 2012·Journal of Lipid Research·Elizebeth C Turner, B Therese Kinsella
Jan 20, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yushi NakayamaKimio Tomita
Dec 14, 2011·Biochemical Pharmacology·Siegfried SchulzRolf Michael Nüsing
Mar 10, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·S Nishio, H Kurumatani
Sep 24, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M M Sailaja Devi, Undurti Narasimha Das
May 24, 2008·Biochimica Et Biophysica Acta·Martina B O'KeeffeB Therese Kinsella
Dec 1, 1993·The British Journal of Surgery·A W BradburyC V Ruckley
May 24, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hidetomo NakamotoToshiro Fujita
Jun 1, 1995·The British Journal of Surgery·C S BerwangerG Stansby
Oct 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T IshimitsuJ M Lange
Nov 22, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M M Sailaja Devi, U N Das
Oct 4, 2008·Cellular Signalling·Katarina WikströmB Therese Kinsella

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