PMID: 3109535May 1, 1987Paper

Cytoprotective effects of disodium cromoglycate on rat stomach mucosa

British Journal of Pharmacology
J GoossensJ P Van Wauwe


The cytoprotective effects of the anti-asthmatic drug, disodium cromoglycate (DSCG), on gastric mucosal necrosis induced by ethanol in rats were studied. Subcutaneous, but not oral, DSCG prevented the formation of gastric lesions and this effect was dose-dependent between 1.25 and 40 mg kg-1, with an ED50 value of 6.8 mg kg-1. Maximal cytoprotection occurred 15-30 min after DSCG treatment. Histological examination revealed that DSCG effectively protected the gastric mucosa against ethanol-induced vascular congestion, haemorrhage, epithelial desquamation and mucosal oedema. Enhanced production of endogenous prostaglandins, which are known cytoprotective compounds, could not explain the mucosal protection. At a dose of 40 mg kg-1, DSCG did not change prostaglandin E2 or 6-keto-prostaglandin F1 alpha concentrations in gastric mucosal tissue, although its cytoprotective activity was partially inhibited by prior treatment of the animals with indomethacin.


May 24, 1975·Lancet·J F BatchelorJ E Tateson
Jan 1, 1977·International Archives of Allergy and Applied Immunology·J El-Azab, P B Stewart
Nov 1, 1978·Histopathology·E CutzD M Cooper
Feb 1, 1986·Lancet·P J Barnes
Jan 1, 1985·International Archives of Allergy and Applied Immunology·J MorleyS Sanjar
Jun 1, 1985·Canadian Journal of Physiology and Pharmacology·D F Biggs, V Goel
Apr 1, 1985·The American Review of Respiratory Disease·L A LaitinenT Haahtela
Jul 1, 1972·The Journal of Pharmacy and Pharmacology·S R WalkerJ W Paterson
Jan 1, 1960·Journal of Clinical Pathology·M S DUNNILL

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