PMID: 22555028May 5, 2012Paper

Cytoprotective role of the aqueous extract of Terminalia chebula on renal epithelial cells

International Braz J Urol : Official Journal of the Brazilian Society of Urology
S TayalC Tandon

Abstract

Kidney stone is one of the most prevalent diseases worldwide. Calcium oxalate (CaOx) has been shown to be the main component of the majority of stones formed in the urinary system of the patients with urolithiasis. The present study evaluates the antilithiatic properties of Terminalia chebula commonly called as ″harad ″ which is often used in ayurveda to treat various urinary diseases including kidney stones. The antilithiatic activity of Terminalia chebula was investigated on nucleation and growth of the calcium oxalate crystals. The protective potency of the plant extract was also tested on oxalate induced cell injury of both NRK-52E and MDCK renal epithelial cells. The percentage inhibition of CaOx nucleation was found 95.84 % at 25µg/mL of Terminalia chebula aqueous extract which remained almost constant with the increasing concentration of the plant extract; however, plant extract inhibited CaOx crystal growth in a dose dependent pattern. When MDCK and NRK-52E cells were injured by exposure to oxalate for 48 hours, the aqueous extract prevented the injury in a dose-dependent manner. On treatment with the different concentrations of the plant extract, the cell viability increased and lactate dehydrogenase release decreased ...Continue Reading

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Citations

Dec 3, 2014·Chemico-biological Interactions·Sarmistha SahaAnupama Pandrangi
May 7, 2013·Expert Opinion on Pharmacotherapy·Frank StrittmatterPetter Hedlund
Nov 29, 2014·Pharmaceutical Biology·Maliheh SafaviAlireza Foroumadi
Jul 23, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·D SujathaS Sunitha
Dec 23, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·A MittalC Tandon
Mar 10, 2018·International Journal of Molecular Sciences·Mina Cheraghi NirumandAnupam Bishayee
May 1, 2013·Lupus·P Vachvanichsanong, E McNeil

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