Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: multi-institutional experience

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Tristan D YanPaul H Sugarbaker

Abstract

This multi-institutional registry study evaluated cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for diffuse malignant peritoneal mesothelioma (DMPM). A multi-institutional data registry that included 405 patients with DMPM treated by a uniform approach that used CRS and HIPEC was established. The primary end point was overall survival. The secondary end point was evaluation of prognostic variables for overall survival. Follow-up was complete in 401 patients (99%). The median follow-up period for the patients who were alive was 33 months (range, 1 to 235 months). The mean age was 50 years (standard deviation [SD], 14 years). Three hundred eighteen patients (79%) had epithelial tumors. Twenty-five patients (6%) had positive lymph nodes. The mean peritoneal cancer index was 20. One hundred eighty-seven patients (46%) had complete or near-complete cytoreduction. Three hundred seventy-two patients (92%) received HIPEC. One hundred twenty-seven patients (31%) had grades 3 to 4 complications. Nine patients (2%) died perioperatively. The mean length of hospital stay was 22 days (SD, 15 days). The overall median survival was 53 months (1 to 235 months), and 3- and 5-year survival rates were ...Continue Reading

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References

Dec 25, 1992·Cancer·K S SridharM Saldana
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·M Markman, D Kelsen
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G LosJ G McVie
Jan 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K AntmanJ Corson
Jan 1, 1995·Annals of Surgery·P H Sugarbaker
Dec 1, 1994·Occupational and Environmental Medicine·R SpirtasJ Benichou
Jan 1, 1996·Cancer Treatment and Research·P Jacquet, P H Sugarbaker
Jun 13, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P J van de VaartA C Begg
Jul 21, 1999·Der Pathologe·V NeumannM Fischer
Oct 22, 2003·Surgical Oncology Clinics of North America·Paul H SugarbakerOlivier Glehen
Oct 22, 2003·Surgical Oncology Clinics of North America·Robert P Sticca, Brian W Dach
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew L FeldmanH Richard Alexander
Sep 1, 2005·International Journal of Occupational and Environmental Health·Laura S WelchPaul H Sugarbaker
Oct 14, 2005·The New England Journal of Medicine·Bruce W S Robinson, Richard A Lake
Jun 30, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T D YanP H Sugarbaker
Oct 19, 2006·The British Journal of Surgery·T D YanP H Sugarbaker
Jul 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George R SimonHedy L Kindler

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Citations

Mar 31, 2012·International Journal of Clinical Oncology·Emanuel CavazzoniAnnibale Donini
Mar 30, 2011·Current Treatment Options in Oncology·Keli M TurnerH Richard Alexander
Apr 20, 2011·Current Oncology Reports·Nagio TakigawaTakumi Kishimoto
Dec 16, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Wenceslao Vásquez JiménezSantiago González Moreno
Apr 6, 2012·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Umut SarpelRussell S Berman
Nov 8, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C CaoUNKNOWN Peritoneal Surface Malignancy Group
Apr 24, 2010·The American Journal of Surgical Pathology·Anna R LauryMichelle S Hirsch
Feb 12, 2011·Annals of Surgical Oncology·Pablo Ortega-DeballonPatrick Rat
Dec 13, 2012·Annals of Surgical Oncology·Nicholas P SchaubItzhak Avital
Feb 2, 2013·Annals of Surgical Oncology·Dominique EliasDiane Goéré
Apr 21, 2011·Current Oncology·F MohamedP Sugarbaker
Nov 14, 2013·World Journal of Gastroenterology : WJG·Federico CoccoliniFausto Catena
Jul 21, 2012·World Journal of Gastrointestinal Surgery·Ioannis T KonstantinidisEvan S Ong
Dec 11, 2013·Annals of Surgical Oncology·Deepa MaggeHaroon A Choudry
Nov 20, 2013·Langenbeck's Archives of Surgery·Yakup KuluAlexis Ulrich
Mar 26, 2014·Cancer Chemotherapy and Pharmacology·Carlos Pérez-RuixoBelén Valenzuela
Apr 15, 2014·International Journal of Colorectal Disease·Mathilde FeistWolfgang Dubiel
Aug 12, 2014·Indian Journal of Cancer·N DharmadhikariP Jagannath
Nov 12, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G PassotE Cotte
May 21, 2014·Annals of Surgical Oncology·John T MiuraKiran K Turaga

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