Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastases From a Small Bowel Adenocarcinoma: Multi-Institutional Experience

Annals of Surgical Oncology
Yang LiuBIG-RENAPE Group

Abstract

The multi-institutional registry in this study evaluated the outcome after cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with peritoneal metastases (PM) from small bowel adenocarcinoma (SBA). A multi-institutional data registry including 152 patients with PM from SBA was established. The primary end point was overall survival (OS) after CRS plus HIPEC. Between 1989 and 2016, 152 patients from 21 institutions received a treatment of CRS plus HIPEC. The median follow-up period was 20 months (range 1-100 months). Of the 152 patients, 70 (46.1%) were women with a median age of 54 years. The median peritoneal cancer index (PCI) was 10 (mean 12; range 1-33). Completeness of cytoreduction (CCR) 0 or 1 was achieved for 134 patients (88.2%). After CRS and HIPEC, the median OS was 32 months (range 1-100 months), with survival rates of 83.2% at 1 year, 46.4% at 3 years, and 30.8% at 5 years. The median disease-free survival after CCR 0/1 was 14 months (range 1-100 months). The treatment-related mortality rate was 2%, and 29 patients (19.1%) experienced grades 3 or 4 operative complications. The period between detection of PM and CRS plus HIPEC was 6 months or less (P = 0.008), and multivar...Continue Reading

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Citations

Mar 7, 2020·Expert Opinion on Drug Delivery·Wim CeelenKatrien Remaut
Nov 7, 2018·Current Treatment Options in Oncology·Alberto PucciniHeinz-Josef Lenz
Jul 15, 2020·Journal of Surgical Oncology·Jason M FosterAllison M Cushman-Vokoun
Aug 14, 2020·Expert Opinion on Pharmacotherapy·Yutaka YonemuraKazurou Nishihara
Mar 11, 2020·Current Problems in Surgery·Adam C FieldsNelya Melnitchouk
Feb 19, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Celine GarrettCherry Koh
Apr 10, 2021·Current Problems in Surgery·John H StewartKonstantinos I Votanopoulos
Dec 7, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Pierre RompteauxThomas Aparicio
Jul 3, 2021·Cancers·Wim CeelenIgnace de Hingh

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Methods Mentioned

BETA
surgical
hysterectomy
pancreatectomy

Software Mentioned

Statistical Package for Social Sciences

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