PMID: 22583426May 16, 2012Paper

Cytoskeletal alterations that confer resistance to anti-tubulin chemotherapeutics

Anti-cancer Agents in Medicinal Chemistry
Arun KanakkantharaJohn H Miller

Abstract

Drugs that target microtubules are a successful class of anti-cancer agents that have been in clinical use for over two decades. Acquired resistance to these drugs, however, remains a serious problem. Microtubule alterations, such as tubulin mutations and altered β- tubulin isotype expression, are prominent factors in development of resistance. Changes in actin and intermediate filament proteins can also mediate sensitivity to microtubule-targeting drugs. This review focuses on the mechanisms by which alterations in cytoskeletal proteins lead to drug resistance. This information will be helpful for improving the targeting of microtubule toxins.

Citations

Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mohamed SaeedThomas Efferth
May 29, 2014·Journal of Cachexia, Sarcopenia and Muscle·Shailendra Kapoor
Feb 11, 2015·Biochimica Et Biophysica Acta·Viswanath DasJohn H Miller
Sep 14, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Ruud H WijdevenJacques Neefjes
May 4, 2017·International Journal of Molecular Sciences·Jessica J FieldJohn H Miller
May 17, 2018·British Journal of Haematology·Susanne Bram EdnerssonPer-Ola Andersson
Oct 1, 2019·Clinical and Molecular Hepatology·Ankita MakolAnuradha Chakraborti
Sep 12, 2020·Journal for Immunotherapy of Cancer·Leylah DrusboskySandeep Bobby Reddy

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