PMID: 9426171Jan 13, 1998Paper

Cytoskeletal changes correlated with the loss of neuronal polarity in axotomized lamprey central neurons

Journal of Neurocytology
G F HallK Kosik

Abstract

Axotomy within 500 microm of the soma (close axotomy) causes identified neurons (anterior bulbar cells or ABCs) in the lamprey hindbrain to lose their normal polarity and regenerate axons ectopically from dendritic tips, while axotomy at more distal sites (distant axotomy) results in orthotopic axonal regeneration from the axon stump. We performed immunocytochemical, electron microscopic and in situ hybridization analyses comparing ABCs subjected to close and distant axotomy to elucidate the mechanism by which neuronal polarity is lost. We show that polarity loss in ABCs is selectively and invariably preceded and accompanied by the following cellular changes: (1) a loss of many dendritic microtubules and their replacement with neurofilaments, (2) a loss of immunostaining for acetylated tubulin in the soma and proximal dendrites, and (3) an increase of immunostaining for phosphorylated neurofilaments in the distal dendrites. We also show that these changes do not depend on either the upregulation or spatial redistribution of neurofilament message, and thus must involve changes in the routing of neurofilament protein within axotomized ABCs. We conclude that close axotomy causes dendrites to undergo axonlike changes in the mechani...Continue Reading

Citations

Jul 29, 2020·Frontiers in Cellular Neuroscience·William RodemerMichael E Selzer
Apr 4, 2001·The European Journal of Neuroscience·P K RoseM Neuber-Hess
Feb 27, 2004·The Journal of Comparative Neurology·Guixin ZhangMichael E Selzer
Jan 28, 2005·Neurorehabilitation and Neural Repair·Guixin ZhangMichael E Selzer
Apr 23, 2009·Neurotoxicity Research·Nicolette S HonsonJeff Kuret
May 28, 2011·The Journal of Comparative Neurology·Guixin ZhangMichael E Selzer
Nov 5, 2003·Journal of Neurobiology·Peter W Baas, Daniel W Buster
Nov 8, 2008·Annals of the New York Academy of Sciences·Robert L RuffMichael E Selzer
Apr 28, 2016·The Journal of Comparative Neurology·Li-Qing JinMichael E Selzer
Oct 24, 2006·Journal of Neurobiology·Steven L JonesGianluca Gallo
Dec 21, 2013·The Journal of Comparative Neurology·Guixin ZhangMichael E Selzer
Apr 1, 2009·Journal of Neurotrauma·Clara PenasXavier Navarro
Jul 10, 2003·Lancet Neurology·Michael E Selzer
Nov 18, 2010·Brain Research·Li-Qing JinMichael E Selzer

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