PMID: 6408100Jul 1, 1983Paper

Cytoskeletal components of the vertebrate neuromuscular junction: vinculin, alpha-actinin, and filamin

The Journal of Cell Biology
R J Bloch, Z W Hall

Abstract

We have used immunocytochemical methods to investigate the cytoskeletal constituents of the vertebrate neuromuscular junction. Specific, affinity-purified antibodies to three cytoskeletal proteins, vinculin, alpha-actinin, and filamin, bound to neuromuscular junctions in sections of normal rat, mouse, chick, and Xenopus muscles. All three antibodies bound to the synaptic regions of denervated rat muscle fibers, indicating that the proteins recognized by these antibodies are associated with postsynaptic structures. The three proteins are present at the neuromuscular junction in muscle fibers of embryonic and neonatal animals, and therefore, may play an important role in its differentiation.

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Citations

Jan 1, 1997·Cell Motility and the Cytoskeleton·G A PorterR J Bloch
Nov 1, 1995·Muscle & Nerve·R MassaG Bernardi
Jan 1, 1989·Molecular Neurobiology·R Laufer, J P Changeux
Apr 1, 1985·Mechanisms of Ageing and Development·R O KelleyL F Marek
Jan 1, 1988·Pharmacology & Therapeutics·F J Barrantes
Jul 20, 2002·Brain Research. Developmental Brain Research·Sunghee KimPhillip G Nelson
Oct 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tomasz J ProszynskiJoshua R Sanes
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D A HarrisG D Fischbach
Mar 1, 1986·The Journal of Cell Biology·M J Anderson
Apr 1, 1986·The Journal of Cell Biology·R J Bloch
Oct 1, 1986·The Journal of Cell Biology·J G TidballK Burridge
Jan 1, 1987·The Journal of Cell Biology·L L Englander, L L Rubin
Mar 1, 1987·The Journal of Cell Biology·J D Siliciano, S W Craig
Sep 1, 1988·The Journal of Cell Biology·L S MusilJ P Merlie
Feb 1, 1989·The Journal of Cell Biology·R J Bloch, J S Morrow
Jun 1, 1990·The Journal of Cell Biology·M VelezD Axelrod
Jul 1, 1991·The Journal of Cell Biology·S C Froehner
Nov 1, 1991·The Journal of Cell Biology·J E YeadonS J Burden
Jan 1, 1992·The Journal of Cell Biology·R J Bloch
Jul 1, 1993·The Journal of Cell Biology·S J SamuelssonR J Bloch

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