Cytoskeletal control of nuclear arrangement in Langhans multinucleate giant cells

The Journal of Pathology
P J Rigby, J M Papadimitriou

Abstract

Examination of the role of the cytoskeleton in macrophage polykarya (multinucleate giant cells) has established that microfilaments and microtubules are interrelated and contractile cytoskeletal components with opposing actions; when critically maintained at equilibrium, they are responsible for maintenance of the highly organized cellular architecture characteristic of Langhans type syncytia. Disruption of the function of these structures by in vitro incubation with cytochalasin B and/or colchicine can result in reversion to a cytoarchitecture which is more typical of the 'foreign body' multinucleate giant cell. These observations strongly reinforce previous suggestions that Langhans multinucleate giant cells are special, more highly organized forms than are 'foreign body' multinucleate giant cells.

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Citations

Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·C FiorentiniG Donelli
Dec 17, 2008·Clinical and Experimental Immunology·T C M Th van MaarsseveenP J van Diest
May 20, 2000·Photochemistry and Photobiology·M BråthenJ Moan
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