Cytoskeletal modifications induced by 4-hydroxynonenal.

Cytotechnology
E GadoniL Gabriel

Abstract

The antiproliferative action of 4-hydroxynonenal (HNE) could be related to an interaction with cytoskeletal structures. In this paper the effects exerted by HNE on microtubules and on microfilaments are examined by immunofluorescence. HNE alters cell morphology causing both the depolymerization of the microtubular structures and the dissolution of the stress-fibres. Taxol protects microtubules, preventing the depolymerizing effect of the aldehyde. The action of HNE could be attributed to its affinity for sulphydryl groups, which are essential in maintaining tubulin and actin both in the polymerized form.

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Citations

Jan 16, 2004·Experimental Gerontology·Vadim V DavydovAnatoly I Bozhkov
Nov 26, 2011·Antioxidants & Redox Signaling·D Allan ButterfieldRukhsana Sultana
Mar 25, 2008·Cell Structure and Function·June KokuboTakao Arai
Dec 31, 2011·Free Radical Biology & Medicine·G MuzioR A Canuto
Feb 19, 2008·Urology·Rik de JonghPhilip E V van Kerrebroeck
Jul 26, 2011·Free Radical Biology & Medicine·Tanea T Reed

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