PMID: 2510038Sep 1, 1989Paper

Cytoskeletal protein pathology and the formation of beta-amyloid fibers in Alzheimer's disease

Neurobiology of Aging
H M WisniewskiJ Currie

Abstract

Discovery of the abnormally phosphorylated tau in paired helical filaments, its accumulation preceding the formation of the tangles and the in vitro microtubule assembly defect suggest that an abnormality in the protein phosphorylation/dephosphorylation system is involved in the pathogenesis of Alzheimer cytoskeletal pathology. The levels of mRNA for the beta-amyloid precursor protein (beta APP) in the brain suggest that only a small deficiency in the processing of the precursor would be sufficient to account for the accumulation of beta-amyloid in Alzheimer brain. Identification of reticuloendothelial system cells responsible for the production/processing of beta-amyloid will help to elucidate the pathogenesis of the brain amyloidosis. The disproportionate accumulation of paired helical filaments and amyloid within the same affected brain and from disease to disease raises the possibility of different etiologies for each of these lesions coexisting in Alzheimer's disease.

References

Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K S KosikD J Selkoe
Jan 1, 1989·Acta Neuropathologica·H M WisniewskiJ Currie
Nov 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·H M WisniewskiB Lach
Jan 1, 1988·Alzheimer Disease and Associated Disorders·S S Matsuyama
Jan 1, 1987·Acta Neuropathologica·S A BobinH M Wisniewski

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Citations

Sep 21, 2013·Acta Neuropathologica·Patrick L McGeer, Edith G McGeer
Sep 1, 1992·Neurobiology of Aging·C W CotmanA Copani
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S A FrautschyG M Cole
Jun 12, 2018·Indian Journal of Surgical Oncology·Surbhi KansalShashi Dhawan
Dec 10, 2017·Oncotarget·Cui-Ping GuoXiao-Chuan Wang
Nov 14, 1997·International Journal of Cancer. Journal International Du Cancer·T ShimazuiJ A Schalken
Apr 13, 1999·The American Journal of Physiology·J K MaesakaM E El-Sabban
Feb 17, 2017·Aging and Disease·Murugesan RajuK Krishna Sharma

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