Cytoskeletal Repair: Microtubule Orthopaedics to the Rescue.

Current Biology : CB
Kevin C Slep

Abstract

While the dynamics of microtubule ends are well characterized, the mechanism that repairs breaks in the lattice interior is poorly understood. A new in vitro study finds that the microtubule-associated protein CLASP repairs lattice damage by regulating GTP-tubulin incorporation into the break site.

References

Sep 25, 2007·Molecular Cell·Kevin C Slep, Ronald D Vale
Jan 25, 2012·PloS One·Carolina TropiniJonathon Howard
May 25, 2015·Journal of Molecular Biology·Takahisa MakiIkuko Hayashi
Sep 8, 2015·Nature Materials·Laura SchaedelManuel Théry
Oct 7, 2015·Nature Communications·Yalei Chen, William O Hancock
Sep 13, 2016·Nature Cell Biology·Charlotte AumeierManuel Théry
May 18, 2017·The Journal of Cell Biology·Amy E Byrnes, Kevin C Slep
Mar 16, 2018·Molecular Biology of the Cell·Elizabeth J LawrenceMarija Zanic
Jun 1, 2018·Molecular Biology of the Cell·Shreoshi MajumdarLuke M Rice
Jun 26, 2018·Developmental Cell·Amol AherAnna Akhmanova
Dec 24, 2019·Nature Physics·Laura SchaedelKarin John

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