Cytoskeletal social networking in the growth cone: How +TIPs mediate microtubule-actin cross-linking to drive axon outgrowth and guidance

Cytoskeleton
Garrett M CammarataL A Lowery

Abstract

The growth cone is a unique structure capable of guiding axons to their proper destinations. Within the growth cone, extracellular guidance cues are interpreted and then transduced into physical changes in the actin filament (F-actin) and microtubule cytoskeletons, providing direction and movement. While both cytoskeletal networks individually possess important growth cone-specific functions, recent data over the past several years point towards a more cooperative role between the two systems. Facilitating this interaction between F-actin and microtubules, microtubule plus-end tracking proteins (+TIPs) have been shown to link the two cytoskeletons together. Evidence suggests that many +TIPs can couple microtubules to F-actin dynamics, supporting both microtubule advance and retraction in the growth cone periphery. In addition, growing in vitro and in vivo data support a secondary role for +TIPs in which they may participate as F-actin nucleators, thus directly influencing F-actin dynamics and organization. This review focuses on how +TIPs may link F-actin and microtubules together in the growth cone, and how these interactions may influence axon guidance. © 2016 Wiley Periodicals, Inc.

References

Oct 1, 1992·Molecular Biology of the Cell·D N DrechselM W Kirschner
Oct 1, 1991·The Journal of Cell Biology·E M Tanaka, M W Kirschner
Oct 1, 1991·The Journal of Cell Biology·J H SabryD Bentley
Nov 1, 1988·Neuron·T Mitchison, M Kirschner
Jun 1, 1971·The Journal of Cell Biology·K M YamadaN K Wessells
Dec 1, 1984·The Journal of Cell Biology·L Marsh, P C Letourneau
Nov 15, 1984·Nature·T Mitchison, M Kirschner
Aug 1, 1981·Journal of Neurocytology·D Bray, M B Bunge
Jan 1, 1995·The Journal of Cell Biology·E Tanaka, M W Kirschner
Jan 1, 1995·The Journal of Cell Biology·E TanakaM W Kirschner
Oct 1, 1994·Current Opinion in Neurobiology·C H LinP Forscher
Feb 1, 1994·Current Opinion in Neurobiology·D Bentley, T P O'Connor
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·T E Holy, S Leibler
Jun 18, 1993·Cell·D V VactorC S Goodman
Sep 20, 1996·The Journal of Biological Chemistry·S KurodaK Kaibuchi
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·T WilliamsonJ Taylor
Sep 26, 1997·The Journal of Biological Chemistry·J W EricksonM J Hart
Dec 31, 1997·The Journal of Biological Chemistry·M FukataK Kaibuchi
Dec 29, 1998·The Journal of Biological Chemistry·Y D HoD B Sacks
Mar 19, 1999·Science·F Bradke, C G Dotti
Sep 3, 1999·The Journal of Biological Chemistry·M FukataK Kaibuchi
Feb 19, 2000·Current Opinion in Neurobiology·L M Lanier, F B Gertler
Jan 9, 2001·Nature Cell Biology·T IshizakiS Narumiya
Jan 13, 2001·Genes & Development·E Fuchs, I Karakesisoglou
Aug 3, 2001·Nature Cell Biology·A F PalazzoG G Gundersen
Jan 26, 2002·The Journal of Biological Chemistry·Scott C MateerGeorge S Bloom
May 30, 2002·The Journal of Cell Biology·Feng-Quan ZhouChristopher S Cohan
Jul 12, 2002·Cell·Masaki FukataKozo Kaibuchi
Jul 2, 2003·Nature Cell Biology·Olga C RodriguezClare M Waterman-Storer
Nov 5, 2003·Journal of Neurobiology·Phillip R Gordon-Weeks
Nov 5, 2003·Journal of Neurobiology·Feng-Quan Zhou, Christopher S Cohan
Nov 26, 2003·Cell·Atsuko KodamaElaine Fuchs
Jan 22, 2005·Current Opinion in Cell Biology·Anna Akhmanova, Casper C Hoogenraad

❮ Previous
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Citations

Oct 26, 2016·Brain Research Bulletin·Almudena Pacheco, Gianluca Gallo
Jan 18, 2017·Genesis : the Journal of Genetics and Development·Paula G SlaterLaura Anne Lowery
Feb 6, 2017·Molecular and Cellular Neurosciences·Loredana LombardiMaria Egle De Stefano
Jan 27, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Paula G SlaterLaura Anne Lowery
Sep 22, 2019·The Journal of Cell Biology·Melody AtkinsCoralie Fassier
Jun 5, 2020·The Journal of Cell Biology·Carlos Sánchez-HuertasJérôme Boudeau
Aug 2, 2018·Frontiers in Cellular Neuroscience·Alexa KissFriedrich Propst
Dec 12, 2018·Frontiers in Cellular Neuroscience·Kyle E Miller, Daniel M Suter
Mar 15, 2018·The Journal of Cell Biology·Coralie FassierJamilé Hazan
Oct 17, 2018·Nature Reviews. Molecular Cell Biology·Marileen Dogterom, Gijsje H Koenderink
Nov 20, 2018·Frontiers in Cellular Neuroscience·Erin M Craig
Aug 14, 2019·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Michihiro Igarashi
Aug 4, 2020·Neural Development·Vivian T ChouDavid Van Vactor
Jul 3, 2018·Frontiers in Cellular Neuroscience·Micaela LasserLaura Anne Lowery
Apr 22, 2020·Proceedings of the National Academy of Sciences of the United States of America·Julio C Corral-SerranoRob W J Collin
Jul 13, 2019·Frontiers in Physiology·Micaela LasserLaura Anne Lowery
May 24, 2020·International Journal of Molecular Sciences·Sung Wook Kim, Kyong-Tai Kim
Nov 11, 2017·Brain Sciences·Darrell Wiens, M Catherine DeSoto
Jan 13, 2018·Neural Regeneration Research·István FoldiJózsef Mihály
Jul 1, 2020·Annual Review of Cell and Developmental Biology·Kristian Franze
Feb 3, 2021·Neuroscience Letters·Rita Pinto-Costa, Monica Mendes Sousa
Mar 6, 2021·Biochemical and Biophysical Research Communications·Jorge A Sierra-FonsecaSukla Roychowdhury
Aug 8, 2021·International Journal of Molecular Sciences·Miguel E Domínguez-Romero, Paula G Slater

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