PMID: 20625675Jul 14, 2010Paper

Cytoskeleton and mechanotransduction in the pathophysiology of ventilator-induced lung injury

Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Leandro Utino TaniguchiElnara Márcia Negri

Abstract

Although mechanical ventilation is an important therapy, it can result in complications. One major complication is ventilator-induced lung injury, which is caused by alveolar hyperdistension, leading to an inflammatory process, with neutrophilic infiltration, hyaline membrane formation, fibrogenesis and impaired gas exchange. In this process, cellular mechanotransduction of the overstretching stimulus is mediated by means of the cytoskeleton and its cell-cell and cell-extracellular matrix interactions, in such a way that the mechanical stimulus of ventilation is translated into an intracellular biochemical signal, inducing endothelial activation, pulmonary vascular permeability, leukocyte chemotaxis, cytokine production and, possibly, distal organ failure. Clinical studies have shown the relationship between pulmonary distension and mortality in patients with ventilator-induced lung injury. However, although the cytoskeleton plays a fundamental role in the pathogenesis of ventilator-induced lung injury, there have been few in vivo studies of alterations in the cytoskeleton and in cytoskeleton-associated proteins during this pathological process.

References

Apr 1, 1991·Journal of Applied Physiology·J B WestR Prediletto
Aug 1, 1990·Journal of Applied Physiology·R R Mercer, J D Crapo
Nov 1, 1989·Journal of Applied Physiology·E H Oldmixon, F G Hoppin
May 1, 1989·Journal of Applied Physiology·L A HernandezJ C Parker
Apr 1, 1987·Journal of Applied Physiology·R R MercerJ D Crapo
May 1, 1970·Journal of Applied Physiology·J MeadD Leith
Dec 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J C ParkerJ Thigpen
Mar 1, 1994·Molecular and Cellular Biology·M D SchallerJ T Parsons
Jan 1, 1993·Critical Care Medicine·J C ParkerK J Peevy
Mar 1, 1997·The Journal of Clinical Investigation·L TremblayA S Slutsky
Jan 1, 1997·Annual Review of Physiology·D E Ingber
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·D Dreyfuss, G Saumon
Feb 5, 1998·The New England Journal of Medicine·M B AmatoC R Carvalho
Jul 29, 1999·Chest·A S Slutsky
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Aug 3, 2000·Intensive Care Medicine·C C dos Santos, A S Slutsky
Sep 28, 2000·Journal of Applied Physiology·C C Dos Santos, A S Slutsky
Mar 7, 2001·Biology of the Cell·V Petit, J P Thiery
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·J D RicardG Saumon
Oct 19, 2001·Oncogene·M D Schaller
Jul 23, 2002·Journal of Applied Physiology·Deborah A QuinnCharles A Hales
Sep 3, 2002·Current Opinion in Critical Care·Michael R Pinsky
Nov 8, 2002·American Journal of Respiratory and Critical Care Medicine·R Andrew ShanelyScott K Powers
Dec 14, 2002·American Journal of Respiratory and Critical Care Medicine·Ognjen GajicRolf D Hubmayr
Jan 24, 2003·American Journal of Respiratory Cell and Molecular Biology·Sunita BhattacharyaJahar Bhattacharya
Feb 1, 2003·Lancet·Liao PinhuMark Griffiths
Mar 6, 2003·The Journal of Clinical Investigation·Hideo IchimuraJahar Bhattacharya
Mar 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Konstantin G BirukovJoe G N Garcia
Mar 18, 2003·Journal of Cell Science·J Thomas Parsons
Apr 12, 2003·Critical Care Medicine·Jérôme Pugin
May 29, 2003·American Journal of Respiratory and Critical Care Medicine·Didier DreyfussGeorges Saumon
Aug 30, 2003·The European Respiratory Journal. Supplement·J D RicardG Saumon
Oct 1, 2003·Respiratory Physiology & Neurobiology·Susan J GunstAnabelle Opazo Saez
Jan 14, 2004·American Journal of Respiratory and Critical Care Medicine·Stefan UhligArthur S Slutsky
Apr 20, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mir H AliPaul T Schumacker
May 18, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·William A AltemeierRobb W Glenny
Jul 13, 2004·Biochimica Et Biophysica Acta·Michele A WozniakPatricia J Keely
Sep 24, 2004·Physiological Reviews·Michael C Brown, Christopher E Turner
Feb 8, 2005·American Journal of Respiratory and Critical Care Medicine·Nicholas E Vlahakis, Rolf D Hubmayr
Oct 14, 2005·Proceedings of the American Thoracic Society·Bing HanMingyao Liu
Dec 14, 2006·Journal of Cell Science·Ronen Zaidel-BarBenjamin Geiger
Jun 1, 2007·Nature·Xavier TrepatJeffrey J Fredberg
Jul 3, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Leena P DesaiChristopher M Waters

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Citations

Feb 13, 2018·Experimental and Therapeutic Medicine·Jinfeng LiuZhenguang Li
May 15, 2012·American Journal of Respiratory and Critical Care Medicine·Moo Suk ParkIvor S Douglas
Oct 18, 2014·Journal of Applied Physiology·Konstantin G Birukov

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