Cytoskeleton-Associated Protein 4 Is a Novel Serodiagnostic Marker for Lung Cancer

The American Journal of Pathology
Kengo YanagitaYuichi Sato

Abstract

Our aim was to develop a serodiagnostic marker for lung cancer. Monoclonal antibodies were generated, and one antibody designated as KU-Lu-1, recognizing cytoskeleton-associated protein 4 (CKAP4), was studied further. To evaluate the utility of KU-Lu-1 antibody as a serodiagnostic marker for lung cancer, reverse-phase protein array analysis was performed with sera of 271 lung cancer patients and 100 healthy controls. CKAP4 was detected in lung cancer cells and tissues, and its secretion into the culture supernatant was also confirmed. The serum CKAP4 levels of lung cancer patients were significantly higher than those of healthy controls (P < 0.0001), and the area under the curve of receiver-operating characteristic curve analysis was 0.890, with 81.1% sensitivity and 86.0% specificity. Furthermore, the serum CKAP4 levels were also higher in patients with stage I adenocarcinoma or squamous cell carcinoma than in healthy controls (P < 0.0001). Serum CKAP4 levels may differentiate lung cancer patients from healthy controls, and they may be detected early even in stage I non-small cell lung cancer. Serum CKAP4 levels were also significantly higher in lung cancer patients than in healthy controls in the validation set (P < 0.0001). ...Continue Reading

Citations

Jun 5, 2019·Molecular and Cellular Biology·Yoshihito OsugiAkira Kikuchi
Oct 5, 2019·Thoracic Cancer·Yasuhiro HiyoshiKatsuhiko Naoki
Mar 5, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Tommaso A DraganiFrancesca Colombo
May 18, 2020·Proteomics. Clinical Applications·Roberto GasparriLorenzo Spaggiari
Oct 21, 2020·Molecular Neurobiology·Mohammad Azizur RahmanMd Alamin
Jan 6, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hirokazu KimuraAkira Kikuchi
Feb 23, 2021·Frontiers in Molecular Biosciences·Shuang-Xi LiZhi-Yong Guo
Mar 20, 2021·Scientific Reports·Hamel PatelHenrik Zetterberg
Aug 1, 2021·Nanoscale Research Letters·Xin HuangBingdi Chen

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