Cytoskeleton mediated effective elastic properties of model red blood cell membranes

The Journal of Chemical Physics
Rui Zhang, Frank L H Brown

Abstract

The plasma membrane of human red blood cells consists of a lipid bilayer attached to a regular network of underlying cytoskeletal polymers. We model this system at a dynamic coarse-grained level, treating the bilayer as an elastic sheet and the cytoskeletal network as a series of phantom entropic springs. In contrast to prior simulation efforts, we explicitly account for dynamics of the cytoskeletal network, both via motion of the protein anchors that attach the cytoskeleton to the bilayer and through breaking and reconnection of individual cytoskeletal filaments. Simulation results are explained in the context of a simple mean field percolation model and comparison is made to experimental measurements of red blood cell fluctuation amplitudes.

References

Jun 1, 1977·The Journal of Cell Biology·W Birchmeier, S J Singer
Mar 1, 1987·The Journal of Cell Biology·S C LiuJ Palek
Jan 18, 1989·Biochimica Et Biophysica Acta·V Bennett
Nov 1, 1973·Zeitschrift Für Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie·W Helfrich
Feb 1, 1981·The Journal of Cell Biology·V P Patel, G Fairbanks
Aug 4, 1995·Biochemical and Biophysical Research Communications·L BordinV Moret
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·S TuviaS Yedgar
Jul 15, 1988·Physical Review A: General Physics·H S Seung, D R Nelson
Jun 15, 1992·Physical Review. a·D BouzidaR H Swendsen
Mar 15, 1992·Physical Review. a·M A Peterson
Jan 1, 1985·Physical Review. B, Condensed Matter·S FengE Garboczi
Sep 1, 1987·Physical Review. B, Condensed Matter·W Tang, M F Thorpe
Apr 1, 1988·Physical Review. B, Condensed Matter·W Tang, M F Thorpe
Aug 24, 1992·Physical Review Letters· Le Doussal P, L Radzihovsky
Aug 18, 2001·Biophysical Journal·V HeinrichE Evans
Jan 12, 2002·Biochemical and Biophysical Research Communications·Wolfgang H Goldmann, Donald E Ingber
Dec 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gerald Lim H WRanjan Mukhopadhyay
Dec 13, 2002·Current Biology : CB·Arthur S Alberts
Apr 2, 2003·Cell Biology Education·Bruce Alberts, UNKNOWN National Academies
Jul 15, 2003·Physical Review Letters·N GovS Safran
Aug 10, 2004·Biophysical Journal·Gene Lamm, George R Pack
Feb 9, 2005·Physical Review Letters·Lawrence C-L Lin, Frank L H Brown
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Lawrence C-L Lin, Frank L H Brown
Aug 16, 2006·Physical Review Letters·S B Rochal, V L Lorman
Aug 22, 2006·Biophysical Journal·Lawrence C-L LinFrank L H Brown
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ju LiSubra Suresh
Jun 30, 2007·The Journal of Chemical Physics·Ali Naji, Frank L H Brown
Mar 11, 1994·Science·W H Press
Dec 11, 2007·Biophysical Journal·Qiang Zhu, Robert J Asaro
Jan 5, 2008·Annual Review of Physical Chemistry·Frank L H Brown
Sep 21, 1998·Physical Review Letters·Nikolai Gouliaev, John F Nagle
May 1, 2006·Journal of Chemical Theory and Computation·Lawrence C-L Lin, Frank L H Brown

❮ Previous
Next ❯

Citations

Jul 7, 2011·Quarterly Reviews of Biophysics·Frank L H Brown
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·YongKeun ParkMichael S Feld
Jul 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zhangli PengSubra Suresh
Apr 1, 2014·European Biophysics Journal : EBJ·Max Puckeridge, Philip W Kuchel
Feb 5, 2015·Biophysical Journal·Tao ZhangJ M Schwarz
Jul 11, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Taráz E BuckRobert F Murphy
May 21, 2010·Biophysical Journal·Dmitry A FedosovGeorge Em Karniadakis
Feb 11, 2020·Biomechanics and Modeling in Mechanobiology·Robert J Asaro, Qiang Zhu
Aug 16, 2016·Biomechanics and Modeling in Mechanobiology·Thomas M Fischer
Jan 17, 2012·Physical Review Letters·Naomi Oppenheimer, Haim Diamant
Dec 31, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Oded Farago

❮ Previous
Next ❯

Methods Mentioned

BETA
dynamic dissociation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.