Cytoskeleton structure and total methylation of mouse cardiac and lung tissue during space flight.

PloS One
Irina V OgnevaVladimir N Sychev

Abstract

The purpose of this work was to evaluate the protein and mRNA expression levels of multiple cytoskeletal proteins in the cardiac and lung tissue of mice that were euthanized onboard the United States Orbital Segment of the International Space Station 37 days after the start of the SpaceX-4 mission (September 2014, USA). The results showed no changes in the cytoskeletal protein content in the cardiac and lung tissue of the mice, but there were significant changes in the mRNA expression levels of the associated genes, which may be due to an increase in total genome methylation. The mRNA expression levels of DNA methylases, the cytosine demethylases Tet1 and Tet3, histone acetylase and histone deacetylase did not change, and the mRNA expression level of cytosine demethylase Tet2 was significantly decreased.

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Citations

Jan 31, 2019·Stem Cells and Development·Eleonora N Grigoryan, Elena A Radugina
May 30, 2019·Scientific Reports·Sergey S Loktev, Irina V Ogneva
Aug 28, 2021·International Journal of Molecular Sciences·Akhilesh KumarRuth K Globus

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Methods Mentioned

BETA
ISS
dissections
dissection
electrophoresis
PCR

Software Mentioned

Dryad
Image Lab
Primer3Plus
SpaceX
BION

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