PMID: 2365302Jun 1, 1990Paper

Cytosol and nuclear estrogen receptor binding in the preoptic area and hypothalamus of female rats during pregnancy and ovariectomized, nulliparous rats after steroid priming: correlation with maternal behavior

Hormones and Behavior
A L GiordanoJ S Rosenblatt


In a previous study, high nuclear estrogen receptor concentrations in the preoptic area (POA) were found on Day 16 of pregnancy to prime females to respond to a subsequent low dose of estradiol benzoate (EB) after hysterectomy-ovariectomy by exhibiting maternal behavior in 48 hr. Receptor concentrations in the POA were found to be higher than those in the hypothalamus (HYP). The present study investigated when nuclear estrogen receptors increase during pregnancy in POA and when the difference in receptor concentrations between POA and HYP occurs. An attempt was made to reproduce these pregnancy changes with a 16-day treatment of estrogen and progesterone in ovariectomized (OVX), nulliparous rats. In Experiment 1, we measured cytosol and nuclear estrogen receptor concentrations in the POA and HYP of female rats during pregnancy. Nuclear receptor concentrations in the POA increased beginning on Day 10, increased again on Day 16, and continued at this high level for the remainder of pregnancy. Nuclear estrogen receptor concentrations in the HYP remained at a lower level throughout most of pregnancy until Day 22 when they increased significantly. In Experiment 2, we tested the maternal behavior and measured estrogen receptor concen...Continue Reading


Feb 1, 1976·Endocrinology·A J HsuehJ H Clark
Mar 11, 1977·Annals of the New York Academy of Sciences·J H ClarkE J Peck
Feb 1, 1977·Journal of Comparative and Physiological Psychology·M NumanB R Komisaruk
Apr 1, 1975·Physiology & Behavior·H I Siegel, J S Rosenblatt
Sep 1, 1975·Journal of Comparative and Physiological Psychology·J S Rosenblatt, H I Siegel
Sep 1, 1975·Hormones and Behavior·H I Siegel, J S Rosenblatt
Oct 1, 1974·Journal of Comparative and Physiological Psychology·M Numan
Nov 1, 1974·Journal of Neurochemistry·V N LuineB S McEwen
May 1, 1974·Journal of Comparative and Physiological Psychology·A S Fleming, J S Rosenblatt
Apr 1, 1969·Endocrinology·J B Powers, I Zucker
Jun 1, 1984·Molecular and Cellular Endocrinology·J GorskiD Sakai
Feb 23, 1984·Nature·W V WelshonsJ Gorski

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