PMID: 2365302Jun 1, 1990Paper

Cytosol and nuclear estrogen receptor binding in the preoptic area and hypothalamus of female rats during pregnancy and ovariectomized, nulliparous rats after steroid priming: correlation with maternal behavior

Hormones and Behavior
A L GiordanoJ S Rosenblatt

Abstract

In a previous study, high nuclear estrogen receptor concentrations in the preoptic area (POA) were found on Day 16 of pregnancy to prime females to respond to a subsequent low dose of estradiol benzoate (EB) after hysterectomy-ovariectomy by exhibiting maternal behavior in 48 hr. Receptor concentrations in the POA were found to be higher than those in the hypothalamus (HYP). The present study investigated when nuclear estrogen receptors increase during pregnancy in POA and when the difference in receptor concentrations between POA and HYP occurs. An attempt was made to reproduce these pregnancy changes with a 16-day treatment of estrogen and progesterone in ovariectomized (OVX), nulliparous rats. In Experiment 1, we measured cytosol and nuclear estrogen receptor concentrations in the POA and HYP of female rats during pregnancy. Nuclear receptor concentrations in the POA increased beginning on Day 10, increased again on Day 16, and continued at this high level for the remainder of pregnancy. Nuclear estrogen receptor concentrations in the HYP remained at a lower level throughout most of pregnancy until Day 22 when they increased significantly. In Experiment 2, we tested the maternal behavior and measured estrogen receptor concen...Continue Reading

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Citations

Oct 1, 1995·Brain Research. Molecular Brain Research·C K Wagner, J I Morrell
Oct 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R H Fitch, H Feder
Jun 1, 1994·Scandinavian Journal of Psychology·K Larsson
Jan 16, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Aliesha González-ArenasIgnacio Camacho-Arroyo
May 22, 2019·Frontiers in Neuroendocrinology·Matthieu KellerThierry D Charlier

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