PMID: 9416777Jan 1, 1997Paper

Cytosolic estrogen receptor concentrations in the lumbosacral spinal cord fluctuate during the estrous cycle

Life Sciences
S J WilliamsR E Papka

Abstract

Estrogen responsive neurons have been anatomically identified with autoradiographic and immunohistochemical techniques and their distribution mapped in the lumbosacral spinal cord of female rats. Such neurons contain estrogen receptors (ERs). The present study was undertaken to: 1) quantify cytosolic estrogen receptor (ER) concentrations in the lumbosacral spinal cord and 2) determine if there is a relationship between cytosolic ER concentrations and fluctuations in serum estradiol (SE2) levels during the estrous cycle. Lumbosacral spinal segments were removed from intact cycling rats during the morning of proestrus, the afternoon of proestrus, and the morning of estrus, metestrus and diestrus. Trunk blood was collected at euthanasia and SE2 levels were determined using radioimmunoassay. Cytosolic ER concentrations were measured using a dextran-charcoal coated tube method. Concentrations of cytosolic ERs were low during estrus and metestrus, increased during diestrus with maximum concentrations during the afternoon of proestrus. These changes in ER concentrations paralleled SE2 levels measured in intact cycling animals; i.e., during estrus SE2 levels were low, but began to rise during metestrus, diestrus, and during the morning...Continue Reading

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Citations

Mar 17, 2001·Current Pain and Headache Reports·M M Heitkemper, M Jarrett
Jun 7, 2003·The Clinical Journal of Pain·Anna Maria Aloisi
Dec 23, 2014·Autonomic Neuroscience : Basic & Clinical·M Mónica Brauer, Peter G Smith
May 23, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Analía RicheriM Mónica Brauer
Aug 25, 2005·Journal of Neurobiology·Wohaib HasanPeter G Smith
Nov 2, 2002·The Journal of Comparative Neurology·Frank P M KruijverDick F Swaab

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